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Enhanced neoepitope-specific immunity following neoadjuvant PD-L1 and TGF-β blockade in HPV-unrelated head and neck cancer
Jason M. Redman, … , James L. Gulley, Clint T. Allen
Jason M. Redman, … , James L. Gulley, Clint T. Allen
Published June 1, 2023
Citation Information: J Clin Invest. 2023;133(11):e172059. https://doi.org/10.1172/JCI172059.
View: Text | PDF | Amended Article

Enhanced neoepitope-specific immunity following neoadjuvant PD-L1 and TGF-β blockade in HPV-unrelated head and neck cancer

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Authors

Jason M. Redman, Jay Friedman, Yvette Robbins, Cem Sievers, Xinping Yang, Wiem Lassoued, Andrew Sinkoe, Antonios Papanicolau-Sengos, Chyi-Chia Lee, Jennifer L. Marte, Evrim Turkbey, Wojtek Mydlarz, Arjun Joshi, Nyall R. London Jr., Matthew Pierce, Rodney Taylor, Steven Hong, Andy Nguyen, Patrick Soon-Shiong, Jeffrey Schlom, James L. Gulley, Clint T. Allen

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RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse
Jaebeom Cho, … , Mien-Chie Hung, Ho-Young Lee
Jaebeom Cho, … , Mien-Chie Hung, Ho-Young Lee
Published May 15, 2023
Citation Information: J Clin Invest. 2023;133(10):e171901. https://doi.org/10.1172/JCI171901.
View: Text | PDF | Amended Article

RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse

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Authors

Jaebeom Cho, Hye-Young Min, Ho Jin Lee, Seung Yeob Hyun, Jeong Yeon Sim, Myungkyung Noh, Su Jung Hwang, Shin-Hyung Park, Hye-Jin Boo, Hyo-Jong Lee, Sungyoul Hong, Rang-Woon Park, Young Kee Shin, Mien-Chie Hung, Ho-Young Lee

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NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression
Yen-Po Tsao, … , Chang-Youh Tsai, Szu-Ting Chen
Yen-Po Tsao, … , Chang-Youh Tsai, Szu-Ting Chen
Published May 1, 2023
Citation Information: J Clin Invest. 2023;133(9):e171350. https://doi.org/10.1172/JCI171350.
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NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression

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Authors

Yen-Po Tsao, Fang-Yu Tseng, Chih-Wei Chao, Ming-Han Chen, Yi-Chen Yeh, Babamale Olarewaju Abdulkareem, Se-Yi Chen, Wen-Ting Chuang, Pei-Ching Chang, I-Chun Chen, Pin-Hsuan Wang, Chien-Sheng Wu, Chang-Youh Tsai, Szu-Ting Chen

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IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury
Shiqin Xiong, … , Jalees Rehman, Asrar B. Malik
Shiqin Xiong, … , Jalees Rehman, Asrar B. Malik
Published March 1, 2023
Citation Information: J Clin Invest. 2023;133(5):e169500. https://doi.org/10.1172/JCI169500.
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IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

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Authors

Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal, Anke Di, Ming Zhong, Wei Wu, Zhiming Ye, Xiaopei Gao, Gadiparthi N. Rao, Dolly Mehta, Jalees Rehman, Asrar B. Malik

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IL-10–producing Th1 cells possess a distinct molecular signature in malaria
Chelsea L. Edwards, … , Rajiv Kumar, Christian R. Engwerda
Chelsea L. Edwards, … , Rajiv Kumar, Christian R. Engwerda
Published February 15, 2023
Citation Information: J Clin Invest. 2023;133(4):e169299. https://doi.org/10.1172/JCI169299.
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IL-10–producing Th1 cells possess a distinct molecular signature in malaria

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Authors

Chelsea L. Edwards, Susanna S. Ng, Fabian de Labastida Rivera, Dillon Corvino, Jessica A. Engel, Marcela Montes de Oca, Luzia Bukali, Teija C.M. Frame, Patrick T. Bunn, Shashi Bhushan Chauhan, Siddharth Sankar Singh, Yulin Wang, Jinrui Na, Fiona H. Amante, Jessica R. Loughland, Megan S.F. Soon, Nicola Waddell, Pamela Mukhopadhay, Lambros T. Koufariotis, Rebecca L. Johnston, Jason S. Lee, Rachel Kuns, Ping Zhang, Michelle J. Boyle, Geoffrey R. Hill, James S. McCarthy, Rajiv Kumar, Christian R. Engwerda

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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
Marianne R. Spalinger, … , Gerhard Rogler, Michael Scharl
Marianne R. Spalinger, … , Gerhard Rogler, Michael Scharl
Published February 15, 2023
Citation Information: J Clin Invest. 2023;133(4):e169304. https://doi.org/10.1172/JCI169304.
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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

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Authors

Marianne R. Spalinger, Stephanie Kasper, Claudia Gottier, Silvia Lang, Kirstin Atrott, Stephan R. Vavricka, Sylvie Scharl, Petrus M. Gutte, Markus G. Grütter, Hans-Dietmar Beer, Emmanuel Contassot, Andrew C. Chan, Xuezhi Dai, David J. Rawlings, Florian Mair, Burkhard Becher, Werner Falk, Michael Fried, Gerhard Rogler, Michael Scharl

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RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass
Nicolas Bonnet, … , Eleni Douni, Serge Ferrari
Nicolas Bonnet, … , Eleni Douni, Serge Ferrari
Published February 15, 2023
Citation Information: J Clin Invest. 2023;133(4):e169317. https://doi.org/10.1172/JCI169317.
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RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

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Authors

Nicolas Bonnet, Lucie Bourgoin, Emmanuel Biver, Eleni Douni, Serge Ferrari

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Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models
Ming Qi, … , Wencai Ye, Dongmei Zhang
Ming Qi, … , Wencai Ye, Dongmei Zhang
Published February 1, 2023
Citation Information: J Clin Invest. 2023;133(3):e168771. https://doi.org/10.1172/JCI168771.
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Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

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Authors

Ming Qi, Shuran Fan, Maohua Huang, Jinghua Pan, Yong Li, Qun Miao, Wenyu Lyu, Xiaobo Li, Lijuan Deng, Shenghui Qiu, Tongzheng Liu, Weiqing Deng, Xiaodong Chu, Chang Jiang, Wenzhuo He, Liangping Xia, Yunlong Yang, Jian Hong, Qi Qi, Wenqian Yin, Xiangning Liu, Changzheng Shi, Minfeng Chen, Wencai Ye, Dongmei Zhang

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Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice
Hao-Yu Zou, … , Nan-Jie Xu, Suya Sun
Hao-Yu Zou, … , Nan-Jie Xu, Suya Sun
Published February 1, 2023
Citation Information: J Clin Invest. 2023;133(3):e168441. https://doi.org/10.1172/JCI168441.
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Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice

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Authors

Hao-Yu Zou, Lin Guo, Bei Zhang, Si Chen, Xin-Rong Wu, Xian-Dong Liu, Xin-Yu Xu, Bin-Yin Li, Shengdi Chen, Nan-Jie Xu, Suya Sun

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Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control
Federico Perdomo-Celis, … , Olivier Lambotte, Asier Sáez-Cirión
Federico Perdomo-Celis, … , Olivier Lambotte, Asier Sáez-Cirión
Published January 17, 2023
Citation Information: J Clin Invest. 2023;133(2):e167843. https://doi.org/10.1172/JCI167843.
View: Text | PDF | Amended Article

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

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Abstract

Authors

Federico Perdomo-Celis, Caroline Passaes, Valérie Monceaux, Stevenn Volant, Faroudy Boufassa, Pierre de Truchis, Morgane Marcou, Katia Bourdic, Laurence Weiss, Corinne Jung, Christine Bourgeois, Cécile Goujard, Laurence Meyer, Michaela Müller-Trutwin, Olivier Lambotte, Asier Sáez-Cirión

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