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Research Letters

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High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance
Fang Yun Lim, … , Ashleigh B. Theberge, Alpana Waghmare
Fang Yun Lim, … , Ashleigh B. Theberge, Alpana Waghmare
Published December 1, 2023
Citation Information: J Clin Invest. 2023;133(23):e173715. https://doi.org/10.1172/JCI173715.
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High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance

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Abstract

Authors

Fang Yun Lim, Soo-Young Kim, Karisma N. Kulkarni, Rachel L. Blazevic, Louise E. Kimball, Hannah G. Lea, Amanda J. Haack, Maia S. Gower, Terry Stevens-Ayers, Lea M. Starita, Michael Boeckh, Ollivier Hyrien, Joshua T. Schiffer, Ashleigh B. Theberge, Alpana Waghmare

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Cells that survive acute murine SARS-CoV-2 infection are detected nearly exclusively in the respiratory tract
Ruangang Pan, … , David K. Meyerholz, Stanley Perlman
Ruangang Pan, … , David K. Meyerholz, Stanley Perlman
Published November 15, 2023
Citation Information: J Clin Invest. 2023;133(22):e172659. https://doi.org/10.1172/JCI172659.
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Cells that survive acute murine SARS-CoV-2 infection are detected nearly exclusively in the respiratory tract

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Abstract

Authors

Ruangang Pan, David K. Meyerholz, Stanley Perlman

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Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force
Quentin McAfee, … , Zolt Arany, Benjamin L. Prosser
Quentin McAfee, … , Zolt Arany, Benjamin L. Prosser
Published November 9, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI170196.
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Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force

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Abstract

Authors

Quentin McAfee, Matthew A. Caporizzo, Keita Uchida, Kenneth C. Bedi Jr., Kenneth B. Margulies, Zolt Arany, Benjamin L. Prosser

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Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion
Feng Pan, … , Kara L. Davis, Michael L. Cleary
Feng Pan, … , Kara L. Davis, Michael L. Cleary
Published November 2, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI171030.
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Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion

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Abstract

Authors

Feng Pan, Jolanda Sarno, Johan Jeong, Xin Yang, Astraea Jager, Tanja A. Gruber, Kara L. Davis, Michael L. Cleary

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The nociceptin/orphanin-FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia
Garth T. Whiteside, … , Sandra K. Willsie, Stephen C. Harris
Garth T. Whiteside, … , Sandra K. Willsie, Stephen C. Harris
Published October 26, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI171172.
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The nociceptin/orphanin-FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

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Abstract

Authors

Garth T. Whiteside, Donald J. Kyle, Ram P. Kapil, Alessandra Cipriano, Ellie He, Mingyan Zhou, Manjunath S. Shet, Michele Hummel, Terri Knappenberger, Kazuya Fukumura, Yoshiyuki Matsuo, Masahiro Uehira, Shuichi Hiroyama, Nozomi Takai, Sandra K. Willsie, Stephen C. Harris

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High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases
Alisa A. Mueller, … , James A. Lederer, Deepak A. Rao
Alisa A. Mueller, … , James A. Lederer, Deepak A. Rao
Published October 24, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI169619.
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High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases

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Authors

Alisa A. Mueller, Takanori Sasaki, Joshua W. Keegan, Jennifer P. Nguyen, Alec Griffith, Alice M. Horisberger, Thomas Licata, Elizabeth Fieg, Ye Cao, Mehreen Elahee, Kathryne E. Marks, Daimon P. Simmons, Lauren C. Briere, Laurel A. Cobban, J. Carl Pallais, Frances A. High, Melissa A. Walker, Jenny J. Linnoila, Jeffrey A. Sparks, V. Michael Holers, Karen H. Costenbader, Undiagnosed Diseases Network (UDN), David A. Sweetser, Joel B. Krier, Joseph Loscalzo, James A. Lederer, Deepak A. Rao

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IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice
Prashant Rai, … , Gregory A. Taylor, Michael B. Fessler
Prashant Rai, … , Gregory A. Taylor, Michael B. Fessler
Published September 12, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI171982.
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IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice

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Authors

Prashant Rai, Martin Sharpe, Charan K. Ganta, Paul J. Baker, Katrin D. Mayer-Barber, Brian E. Fee, Gregory A. Taylor, Michael B. Fessler

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Vaccine effectiveness of BNT162b2 mRNA Covid-19 vaccine in children under 5 years
Christoph Strumann, … , Cho-Ming Chao, Matthias B. Moor
Christoph Strumann, … , Cho-Ming Chao, Matthias B. Moor
Published September 5, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI173329.
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Vaccine effectiveness of BNT162b2 mRNA Covid-19 vaccine in children under 5 years

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Abstract

Authors

Christoph Strumann, Otavio T. Ranzani, Jeanne Moor, Reinhard Berner, Nicole Toepfner, Cho-Ming Chao, Matthias B. Moor

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No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines
Natalie E. Stevens, … , Nigel Curtis, David J. Lynn
Natalie E. Stevens, … , Nigel Curtis, David J. Lynn
Published July 20, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI171742.
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No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

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Abstract

Authors

Natalie E. Stevens, Feargal J. Ryan, Nicole L. Messina, Stephen J. Blake, Todd S. Norton, Susie Germano, Jane James, Georgina L. Eden, Yee C. Tee, Miriam A. Lynn, Rochelle Botten, Simone E. Barry, Nigel Curtis, David J. Lynn

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Active transcription in the vascular bed characterizes rapid progression in idiopathic pulmonary fibrosis
Nirmal S. Sharma, … , Camilla Margaroli, Amit Gaggar
Nirmal S. Sharma, … , Camilla Margaroli, Amit Gaggar
Published June 29, 2023
Citation Information: J Clin Invest. 2023. https://doi.org/10.1172/JCI165976.
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Active transcription in the vascular bed characterizes rapid progression in idiopathic pulmonary fibrosis

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Abstract

Authors

Nirmal S. Sharma, Kapil Patel, Ezgi Sari, Shruti Shankar, Maria G. Gastanadui, Diego Moncada-Giraldo, Yixel M. Soto-Vázquez, Delores A. Stacks, Louise Hecker, Kevin G. Dsouza, Mudassir Banday, Edward O'Neill, Paul Benson, Gregory A. Payne, Camilla Margaroli, Amit Gaggar

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