Anti-influenza antibody in hemagglutinin head domain interface

In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers.

Salt generates antiinflammatory Th17 cells but amplifies pathogenicity

In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity.

T cells prevent and treat graft-versus-host disease

In this episode, Marco Davila and Brian Betts explain that taking advantage of the differential expression of CD83, human CD83-targeted CAR T cells prevent and treat GVHD, as well as kill myeloid leukemia.

JCI's Conversations with Giants in Medicine: Jesse Roth

We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the groundbreaking work of Jesse Roth and his colleagues. Roth is best known for his research on cell surface membrane receptors. His studies on the receptors for insulin, growth hormone, and adrenocorticotropic hormone (ACTH) in the early 1970s became the model for many others.

Microenvironmental Th9 and Th17 induce spreading in lung cancer

In this episode, Rajkumar Savai and colleagues explain that Th9 and Th17 lymphocytes induce lung cancer cell epithelial-mesenchymal transition via release of their signature cytokines, thereby promoting migration, vessel entry, and metastatic spreading.