Robert Lefkowitz, physician-scientist from Duke University and the 2012 Nobel laureate in chemistry for his studies of GPCRs has recently written a memoir called A Funny Thing Happened on the Way to Stockholm, and we couldn’t resist the opportunity to ask Dr. Lefkowitz to reflect more extensively on a life well lived and a career full of phenomenal insights and ample laughter. Hear his reflections on competition in academia as well as the push and pull of a life as a physician-scientist.
In this episode, Samar Ibrahim explains that lipotoxic stress enhances the expression of LSEC-VCAM-1, in part, through MLK3 signaling. Inhibition of VCAM-1 was salutary in murine NASH, and might serve as a potential therapeutic strategy for human NASH.
In this issue, Edward Thorp explains that AXL uniquely promotes a switch to glycolytic metabolism and inflammatory cytokine production by macrophages to worsen ventricular remodeling and lead to heart failure after myocardial infarction.
In this episode, Erwin Van Meir and Satoru Osuka eplain that glioma stem cells adapt to the toxicity of repeated irradiation by upregulating N-cadherin, and this resistance pathway can be antagonized by blocking the IGF1 receptor.
In this episode, Santiago Lamas and Verónica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD.