Mature myelin maintenance requires Qki to coactivate metabolism

In this episode, Jian Hu and colleagues demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation

In this episode, Vijay Singh and colleagues reveal that Pancreatic lipase-mediated necrosis of visceral fat worsens outcomes in acute pancreatitis.

Conversations with Giants in Medicine: Barbara Kahn

Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for elucidating molecular mechanisms of type 2 diabetes, obesity, and insulin resistance, with a particular emphasis on the role of the adipocyte in regulating glucose metabolism. In this interview by JCI Editor at Large Ushma Neill, Dr. Kahn discusses her work and history, including tales of going to Studio 54 with Andy Warhol.

Interferon signature in undifferentiated systemic autoinflammatory diseases

In this episode, Raphaela Goldbach-Mansky, Adriana de Jesus, and colleagues use a comprehensive approach to identify autoinflammatory diseases that present with elevated interferon signature.

IL-36γ induction underlies EGFR inhibitor-associated skin toxicity

In this episode, Lars French, Takashi K. Satoh and colleagues show that EGFR/MEK inhibitors and the commensal Cutibacterium acnes synergistically induce IL-36γ in keratinocytes, resulting in neutrophilic acneiform skin toxicities.