Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation

In this episode, Vijay Singh and colleagues reveal that Pancreatic lipase-mediated necrosis of visceral fat worsens outcomes in acute pancreatitis.

Conversations with Giants in Medicine: Barbara Kahn

Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for elucidating molecular mechanisms of type 2 diabetes, obesity, and insulin resistance, with a particular emphasis on the role of the adipocyte in regulating glucose metabolism. In this interview by JCI Editor at Large Ushma Neill, Dr. Kahn discusses her work and history, including tales of going to Studio 54 with Andy Warhol.

Interferon signature in undifferentiated systemic autoinflammatory diseases

In this episode, Raphaela Goldbach-Mansky, Adriana de Jesus, and colleagues use a comprehensive approach to identify autoinflammatory diseases that present with elevated interferon signature.

IL-36γ induction underlies EGFR inhibitor-associated skin toxicity

In this episode, Lars French, Takashi K. Satoh and colleagues show that EGFR/MEK inhibitors and the commensal Cutibacterium acnes synergistically induce IL-36γ in keratinocytes, resulting in neutrophilic acneiform skin toxicities.

JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper

Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert Lasker Basic Medical Research Award, Max D. Cooper of Emory University and Jacques Miller of the Walter and Eliza Hall Institute of Medical Research. Drs. Miller and Cooper identified and defined the function of T and B cells, uncovering the organizing principle of the adaptive immune system.