Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes

Persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.

Germ cell tumors and other malignancies evolve from a shared precursor

In this episode, Justin Taylor and colleagues identify the genomic characteristics and clonal origins of a unique and aggressive clinical syndrome involving clonally related hematologic malignancies and germ cell tumors.

Kisspeptin receptor agonist and female reproductive disorders

In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native kisspeptin-54, and thus increased therapeutic potential to treat female reproductive disorders.

Maintenance DNA methylation is essential for development and stability

In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell identity and suppressive function during both development and lineage self-renewal.

Vaccine targeting protects macaques against vaginal infection

In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates of vaccine efficacy.