In this episode, Lasse Giil explains that activation of the kynurenine pathway in delirium leads to high brain concentrations the endogenous neurotoxin quinolinic acid.
In this episode, Nima Sharifi and Xiuxiu Li discuss how the BMX kinase regulates androgen and estrogen biosynthesis and is a drug target for sex steroid dependent cancers.
Lo is often called the father of noninvasive prenatal testing. After discovering fetal DNA in maternal blood, Lo catalyzed a medical revolution that has saved millions of pregnant people from having to undergo invasive tests like amniocentesis. With Lo’s pioneering technical advances, those who are pregnant can easily and reliably be screened for Rh factor mismatch, trisomies, and genetic disorders, and the implications of his work have and may go further in cancer testing, transplantation, and perhaps beyond.
In this episode, Dr. Blanco-Domínguez discusses CD69 expression on regulatory T cells after myocardial infarction controls immune homeostasis and prevents death and chronic heart failure development in mice and humans.
On any given day, over 50 billion of the cells in your body will die. The question of how we live while our cells are continuously dying has captivated Dr. Vishva Dixit. After a long career in academia, Dixit rose through the ranks at Genentech and currently serves as the Vice President of Early Discovery Research. His scientific work has focused on the elucidation of the mechanisms of apoptosis, including the discovery of caspases.