Next-generation sequencing (NGS) applications for the diagnostics of infectious diseases has demonstrated great potential with three distinct approaches: whole-genome sequencing (WGS), targeted NGS (tNGS), and metagenomic NGS (mNGS, also known as clinical metagenomics). These approaches provide several advantages over traditional microbiologic methods, though challenges still exist.
Kyle G. Rodino, Patricia J. Simner
Karthik Vasan, Navdeep S. Chandel
Saptarsi M. Haldar
Timothy M. Errington
Rana K. Gupta
André C. Carpentier, Denis P. Blondin
Aaron M. Cypess
Peter-James H. Zushin, Souhrid Mukherjee, Joseph C. Wu
Yang Gou, Michael W. Schwartz
Simone Tzaridis, Martin Friedlander
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