Viewpoint
Citation Information: J Clin Invest. 2021;131(2):e145964. https://doi.org/10.1172/JCI145964.
Abstract
Authors
Jeffrey C. Rathmell, W. Kimryn Rathmell
Citation Information: J Clin Invest. 2021;131(2):e145965. https://doi.org/10.1172/JCI145965.
Abstract
Authors
Louis J. Ptáček, Ying-Hui Fu
Citation Information: J Clin Invest. 2021;131(2):e145962. https://doi.org/10.1172/JCI145962.
Citation Information: J Clin Invest. 2021;131(2):e145966. https://doi.org/10.1172/JCI145966.
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Authors
Robert V. Farese Jr., Tobias C. Walther
Citation Information: J Clin Invest. 2021. https://doi.org/10.1172/JCI147553.
Abstract
Limited evidence exists regarding the use of the currently approved COVID-19 mRNA vaccines (Pfizer-BioNtech BNT162b2 and Moderna mRNA-1273) during pregnancy. In this Viewpoint, Klein et al. discuss gaps in knowledge and make recommendations to incorporate age, sex, and pregnancy in the preclinical and clincal vaccine development pipeline.
Authors
Sabra L. Klein, Patrick S. Creisher, Irina Burd
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI146391.
Abstract
In this viewpoint, Robert Califf, former commissioner of the U.S. Food and Drug Administration, and colleagues reflect on how to approach questions about which patient treatments and strategies work, particularly in light of the tremendous pressure on the government and biomedical research enterprise to quickly develop safe, effective therapies during the SARS-CoV-2 pandemic.
Authors
Robert M. Califf, Lesley H. Curtis, Robert A. Harrington, Adrian F. Hernandez, Eric D. Peterson
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI146392.
Abstract
Randomized controlled trials are the preferred design for the analysis of health-related interventions. In this Viewpoint, Nigel Paneth and Michael Joyner discuss circumstances when randomized controlled trials might not be feasible and the criteria that should be used when considering applying observational data medicine.
Authors
Nigel Paneth, Michael Joyner
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI145214.
Abstract
Katherine Uyhazi and renowned gene therapy pioneer Jean Bennett share their perspective on the 2020 Nobel Prize in Chemistry awarded to Emmanuelle Charpentier and Jennifer Doudna for their discovery of the CRISPR/Cas9 genetic scissors that have revolutionized genome editing.
Authors
Katherine E. Uyhazi, Jean Bennett
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI145615.
Abstract
Seed grant programs are an efficient mechanism for universities to invest in high-risk ideas, incite collaborative research, support early career faculty, and direct faculty towards a specific goal. At the outset of the COVID-19 pandemic, Johns Hopkins leadership quickly mobilized to support research teams as they pivoted to gather preliminary data and seek solutions to save lives. Here we discuss key lessons learned from the program.
Authors
Julie Messersmith, Chasmine Stoddart-Osumah, Marc Lennon, Denis Wirtz
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI144524.
Abstract
In the wake of the brutal murders of Ahmaud Arbery, Sean Reed, Breonna Taylor, and George Floyd and, amidst international outcries for social justice, many of us are asking ourselves what we can do to effect change. How can we be impactful allies in the medical profession? How can we support and protect our Black students and foster their careers? This Viewpoint examines the importance of improving diversity and inclusion among physicians and scientists at academic institutions .
Authors
Briyana R. Chisholm, Enid R. Neptune, Sherita H. Golden, Linda Resar
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