The Journal of Clinical Investigation -- New Articles https://www.jci.org/current en-us 2026 The American Society for Clinical Investigation The Journal of Clinical Investigation http://www.jci.org/assets/common/jci-only-white-blue-bg.png http://www.jci.org <![CDATA[The perinecrotic niche of glioblastoma drives tumor-associated macrophage polarization and immunosuppression via podoplanin-mediated CLEC5A activation]]> https://www.jci.org/articles/view/199228 info:doi/10.1172/JCI199228 The American Society for Clinical Investigation <![CDATA[Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion]]> https://www.jci.org/articles/view/204602 info:doi/10.1172/JCI204602 The American Society for Clinical Investigation <![CDATA[SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver]]> https://www.jci.org/articles/view/208521 info:doi/10.1172/JCI208521 The American Society for Clinical Investigation <![CDATA[SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activation]]> https://www.jci.org/articles/view/199709 info:doi/10.1172/JCI199709 The American Society for Clinical Investigation <![CDATA[Therapy-resistant lymphomas may want nucleotides, but they just need to grow]]> https://www.jci.org/articles/view/208384 info:doi/10.1172/JCI208384 The American Society for Clinical Investigation <![CDATA[Osteopontin mediates acquired resistance to hypoxia-inducing antiangiogenics and promotes anti–PD-L1 refractoriness in breast cancer models]]> https://www.jci.org/articles/view/174092 info:doi/10.1172/JCI174092 The American Society for Clinical Investigation <![CDATA[Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis]]> https://www.jci.org/articles/view/200755 info:doi/10.1172/JCI200755 The American Society for Clinical Investigation <![CDATA[The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration]]> https://www.jci.org/articles/view/207273 info:doi/10.1172/JCI207273 The American Society for Clinical Investigation <![CDATA[TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration]]> https://www.jci.org/articles/view/190035 info:doi/10.1172/JCI190035 The American Society for Clinical Investigation <![CDATA[Branched chain amino acid metabolism and microbiome in adolescents with obesity during weight loss therapy]]> https://www.jci.org/articles/view/196742 info:doi/10.1172/JCI196742 The American Society for Clinical Investigation <![CDATA[Antigen-specific type 1 regulatory T cell responses shape immunity and disease tolerance in human malaria]]> https://www.jci.org/articles/view/208046 info:doi/10.1172/JCI208046 The American Society for Clinical Investigation <![CDATA[Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures]]> https://www.jci.org/articles/view/199698 info:doi/10.1172/JCI199698 The American Society for Clinical Investigation <![CDATA[Sterol biosynthesis, brain development, and disease]]> https://www.jci.org/articles/view/208000 info:doi/10.1172/JCI208000 The American Society for Clinical Investigation <![CDATA[Gut microbe–derived short-chain fatty acids regulate alphavirus arthritis and macrophage activation in mice]]> https://www.jci.org/articles/view/202262 info:doi/10.1172/JCI202262 The American Society for Clinical Investigation <![CDATA[Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype]]> https://www.jci.org/articles/view/202867 info:doi/10.1172/JCI202867 The American Society for Clinical Investigation <![CDATA[CXCR6+ CD127– Tr1 cells balance immunity and persistence in Plasmodium falciparum infection]]> https://www.jci.org/articles/view/200628 info:doi/10.1172/JCI200628 The American Society for Clinical Investigation <![CDATA[SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape]]> https://www.jci.org/articles/view/198270 info:doi/10.1172/JCI198270 The American Society for Clinical Investigation <![CDATA[Single-cell analysis of fetal testis reveals dysfunction of human Leydig cells in Klinefelter syndrome]]> https://www.jci.org/articles/view/201124 info:doi/10.1172/JCI201124 The American Society for Clinical Investigation <![CDATA[Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes]]> https://www.jci.org/articles/view/204429 info:doi/10.1172/JCI204429 The American Society for Clinical Investigation <![CDATA[Winners of Lasker Foundation Video Contest announced]]> https://www.jci.org/articles/view/210286 info:doi/10.1172/JCI210286 The American Society for Clinical Investigation <![CDATA[Kevin N. Sheth, MD, receives the 2026 Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award]]> https://www.jci.org/articles/view/209633 info:doi/10.1172/JCI209633 The American Society for Clinical Investigation <![CDATA[Targeting CIC::DUX4 sarcoma with Minnelide in a dual recombinase–initiated genetically engineered mouse model]]> https://www.jci.org/articles/view/202218 info:doi/10.1172/JCI202218 The American Society for Clinical Investigation <![CDATA[Targeting hepatic cholesterol sensing to tackle metabolic dysfunction–associated steatohepatitis]]> https://www.jci.org/articles/view/206628 info:doi/10.1172/JCI206628 The American Society for Clinical Investigation <![CDATA[Histone lysine methyltransferases KMT2C and KMT2D join the all-star tumor suppressor team in gastrointestinal cancer]]> https://www.jci.org/articles/view/208392 info:doi/10.1172/JCI208392 The American Society for Clinical Investigation <![CDATA[Loss of Kmt2c/d promotes gastric cancer and confers vulnerability to mTORC1 and PD-1 inhibition]]> https://www.jci.org/articles/view/194462 info:doi/10.1172/JCI194462 The American Society for Clinical Investigation <![CDATA[The splice of life: an isoform-centric view of disease, technology, and therapeutics]]> https://www.jci.org/articles/view/207476 info:doi/10.1172/JCI207476 The American Society for Clinical Investigation <![CDATA[HVEM-LIGHT signaling promotes antibody-dependent neutrophil FcγR-mediated trogocytosis against herpes simplex virus infection]]> https://www.jci.org/articles/view/203771 info:doi/10.1172/JCI203771 The American Society for Clinical Investigation <![CDATA[Cholesterol-responsive NFE2L1-INSIG1 interaction controls VLDL secretion and metabolic dysfunction–associated steatohepatitis pathogenesis in mice]]> https://www.jci.org/articles/view/197094 info:doi/10.1172/JCI197094 The American Society for Clinical Investigation <![CDATA[Single-cell spatial transcriptomics of formalin-fixed, paraffin-embedded biopsies reveals colitis-associated cell networks]]> https://www.jci.org/articles/view/202488 info:doi/10.1172/JCI202488 The American Society for Clinical Investigation <![CDATA[GLUT9b- and ABCG2-mediated collecting duct urate transport uncovers a vasopressin-independent mechanism of renal water reabsorption]]> https://www.jci.org/articles/view/197021 info:doi/10.1172/JCI197021 The American Society for Clinical Investigation