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Author's Take

In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.

Cerebrospinal fluid quinolinic acid and delirium and mortality in hip-fracture patients

In this episode, Lasse Giil explains that activation of the kynurenine pathway in delirium leads to high brain concentrations the endogenous neurotoxin quinolinic acid.


BMX controls in cancer

In this episode, Nima Sharifi and Xiuxiu Li discuss how the BMX kinase regulates androgen and estrogen biosynthesis and is a drug target for sex steroid dependent cancers.


CD69 expression protects from immune damage after MI

In this episode, Dr. Blanco-Domínguez discusses CD69 expression on regulatory T cells after myocardial infarction controls immune homeostasis and prevents death and chronic heart failure development in mice and humans.


Durability of AZD1222 COVID-19 vaccine over 6 months

In this episode, Magdalena Sobieszczyk explains the paper and that it provides comprehensive safety information and data on durability of protection and immunogenicity of AZD1222 after a median follow-up of 6 months.


Immune responses and the rejection of colonized solid organ transplants

In this episode, Isabella Pirozzolo explains that following transplantation, microbiota-colonized organs have a shorter half-life than sterile organs. In the paper, the authors show that host-versus-commensal immunity participates in graft damage independently from alloimmunity.

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