Author's Take
In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Samar Ibrahim explains that lipotoxic stress enhances the expression of LSEC-VCAM-1, in part, through MLK3 signaling. Inhibition of VCAM-1 was salutary in murine NASH, and might serve as a potential therapeutic strategy for human NASH.
In this issue, Edward Thorp explains that AXL uniquely promotes a switch to glycolytic metabolism and inflammatory cytokine production by macrophages to worsen ventricular remodeling and lead to heart failure after myocardial infarction.
In this episode, Erwin Van Meir and Satoru Osuka eplain that glioma stem cells adapt to the toxicity of repeated irradiation by upregulating N-cadherin, and this resistance pathway can be antagonized by blocking the IGF1 receptor.
In this episode, Santiago Lamas and Verónica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD.
In this episode, Ana Greka and Eriene-Heidi Sidhom explain that an investigation of cell-specific disease mechanisms in rare genetic disorder revealed Braf/Mapk as a candidate pathway for the treatment of kidney diseases.
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)