In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
Persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.
In this episode, Justin Taylor and colleagues identify the genomic characteristics and clonal origins of a unique and aggressive clinical syndrome involving clonally related hematologic malignancies and germ cell tumors.
In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native kisspeptin-54, and thus increased therapeutic potential to treat female reproductive disorders.
In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell identity and suppressive function during both development and lineage self-renewal.
In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates of vaccine efficacy.