Interferon signature in undifferentiated systemic autoinflammatory diseases

In this episode, Raphaela Goldbach-Mansky, Adriana de Jesus, and colleagues use a comprehensive approach to identify autoinflammatory diseases that present with elevated interferon signature.

IL-36γ induction underlies EGFR inhibitor-associated skin toxicity

In this episode, Lars French, Takashi K. Satoh and colleagues show that EGFR/MEK inhibitors and the commensal Cutibacterium acnes synergistically induce IL-36γ in keratinocytes, resulting in neutrophilic acneiform skin toxicities.

JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper

Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert Lasker Basic Medical Research Award, Max D. Cooper of Emory University and Jacques Miller of the Walter and Eliza Hall Institute of Medical Research. Drs. Miller and Cooper identified and defined the function of T and B cells, uncovering the organizing principle of the adaptive immune system.

CD8+ T cell function may predict type 1 diabetes progression

In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive CD8⁺ T cells.

Fibronectin variant mediates smooth muscle cell phenotypic switching

In this episode, Anil Chauhan, Manish Jain, and colleagues reveal that smooth muscle cell- specific fibronectin containing an extra domain A mediates phenotypic switching and neointimal hyperplasia.