In this episode, Styliani Karanika describes how their findings underscore the potential of a strategy to advance therapeutic TB vaccine development targeting M. tuberculosis persisters while providing a framework to define correlates of vaccine-mediated protection.
In this episode, Dr. Alexander G. Bick discusses how epidemiology studies underestimate how strongly clonal hematopoiesis is linked to disease because shallow whole-genome sequencing produces more false negatives compared with deep targeted sequencing.
In this episode, Sophie Paczesny explains that BIOPREVENT accurately predicts individual risk of future cGVHD and NRM using biomarkers at 3 months post-HCT. A publicly available R Shiny web application supports its clinical use. Further studies are needed to explore its role in guiding preemptive therapy.
The American Society for Clinical Investigation (ASCI) honors Consuelo H. Wilkins, MD, MSCI, with the 2025 ASCI/Louis W. Sullivan, MD, Award. Dr. Wilkins is recognized for her paradigm-shifting work identifying health disparities and engaging underrepresented groups in clinical research. Dr. Wilkins is Mildred Thornton Stahlman Chair in Rural Health and Professor of Medicine in the Geriatrics Division at Vanderbilt University Medical Center as well as Associate Director for the Vanderbilt Alzheimer’s Disease Research Center and Engagement Core Director of the All of Us Research Program. She served as Founding Director of the Center for Community Health and Partnerships in the Washington University in St. Louis Institute for Public Health, Codirector of the Center for Community-Engaged Research in the Clinical and Translational Science Awards Program, and Director of Our Community, Our Health. Dr. Wilkins was elected to the National Academy of Medicine and, in 2022, the ASCI. Dr. Sherita H. Golden, Past Chair of the ASCI Physician-Scientist Engagement Committee and Hugh P. McCormick Family Professor of Endocrinology and Metabolism at the Johns Hopkins University School of Medicine, interviewed Dr. Wilkins at the AAP/ASCI/APSA Joint Meeting in Chicago in April 2025.
The American Society for Clinical Investigation (ASCI) honors Alexander G. Bick, MD, PhD, with the 2025 ASCI/Seldin~Smith Award for Pioneering Research. Dr. Bick is recognized for his application of computational genomics and experimental techniques to advancing understanding of blood cancer and cardiovascular disease. He is Director of the Division of Genetic Medicine at Vanderbilt University Medical Center and was elected to the ASCI in 2025. Dr. Bick received his MD and PhD in genetics from Harvard and completed a residency at Massachusetts General Hospital (MGH) and fellowship at the Broad Institute. Rajan Jain, MD, ASCI Councilor and William Wikoff Smith Associate Professor in Cardiovascular Research at the University of Pennsylvania Perelman School of Medicine, interviewed Dr. Bick at the AAP/ASCI/APSA Joint Meeting in Chicago in April 2025.