Maintenance DNA methylation is essential for development and stability

In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell identity and suppressive function during both development and lineage self-renewal.

Vaccine targeting protects macaques against vaginal infection

In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates of vaccine efficacy.

JCI's Conversations with Giants in Medicine: C. Ronald Kahn

C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the insulin receptor and the means by which it signals. He previously served as president of the American Society for Clinical Investigation and is the scientist with the most publications in the JCI. See the full interview on the JCI website https://www.jci.org/videos/cgms to hear more about Dr. Kahn’s political aspirations beyond the presidency of ASCI and to hear who told him he’d never be a big deal in endocrinology.

Anti-influenza antibody in hemagglutinin head domain interface

In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers.

Salt generates antiinflammatory Th17 cells but amplifies pathogenicity

In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity.