Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert Lasker Basic Medical Research Award, Max D. Cooper of Emory University and Jacques Miller of the Walter and Eliza Hall Institute of Medical Research. Drs. Miller and Cooper identified and defined the function of T and B cells, uncovering the organizing principle of the adaptive immune system.
In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive CD8+ T cells.
In this episode, Anil Chauhan, Manish Jain, and colleagues reveal that smooth muscle cell- specific fibronectin containing an extra domain A mediates phenotypic switching and neointimal hyperplasia.
Cell biologist Elaine Fuchs of the Rockefeller University is best known for revolutionizing the molecular and genetic study of skin. Her research has shed light on dermatologic disorders and all aspects of skin growth and regeneration. Her more recent work in stem cell biology has revealed broad paradigms that regulate tissue regenerative stem cells across the body, and the mechanisms she has described have major ramifications in cancer and regenerative medicine.
In this episode, Nicolai van Oers and colleagues demonstrate that compound heterozygous mutations in FOXN1 result in a combined immunodeficiency in patients that is distinct Nude/SCID phenotypes.