Distal wound healing is regulated by peritoneal macrophages via endocrine release

In this episode, Guido Beldi and Lilian Salm explain how their findings suggest that large peritoneal macrophages (LPMs), strategically positioned in the peritoneal cavity, serve as a source of circulating fibronectin, promoting matrix formation and accelerating wound healing at distant sites.

Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis

In this episode, Xiang-Yu Liu explains that the manuscript's findings revise the conventional view of GSH in protein redox and demonstrate that targeted redox manipulation through GSH depletion protects against MASLD.

CD8+ T cell neuroimmune surveillance following SIV infection is impaired by α4 integrin

In this episode Smita Iyer describe how the manuscript's findings establish that α4 integrin governs CD8-mediated neuroimmune surveillance through coordinated cellular positioning, with blockade enabling viral seeding while disrupting spatially organized antiviral defense.

A tuberculosis cure is accelerated by immunotherapy targeting

In this episode, Styliani Karanika describes how their findings underscore the potential of a strategy to advance therapeutic TB vaccine development targeting M. tuberculosis persisters while providing a framework to define correlates of vaccine-mediated protection.

Genome/exome sequencing underestimates CHIP–disease associations

In this episode, Dr. Alexander G. Bick discusses how epidemiology studies underestimate how strongly clonal hematopoiesis is linked to disease because shallow whole-genome sequencing produces more false negatives compared with deep targeted sequencing.