JCI’s Conversations with Giants in Medicine: JCI Editors in Chief

In this episode, Ushma Neill speaks with the living Editors in Chief of the Journal of Clinical Investigation. They were asked to reflect on their time as editors and their favorite memories.

A dynamic multilayered tissue architecture is revealed in skeletal muscle

In this episode, Laszlo Nagy and colleagues, explain that macrophages coordinate tissue repair by promoting regenerative inflammation. They discovered diverse myeloid cell subsets that organize in functional multilayered tissue zones, crucial for effective muscle repair.

Happy 100th birthday, JCI!

Former JCI editors in chief wish the Journal of Clinical Investigation a happy 100th birthday!

ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts

In this episode, Rafael Kramann, Konrad Hoeft, and Lars Koch explain that catalytically active ADAMTS12 controls fibrosis by restructuring ECM to enable activation and migration of a distinct injury-responsive fibroblast subset after injury.

Sex- and age-specific differences revealed by mouse sarcopenia models

In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function, and the underlying molecular mechanisms in male and female mice.