Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares
James G. Krueger, … , Christian Thoma, Johann E. Gudjonsson
James G. Krueger, … , Christian Thoma, Johann E. Gudjonsson
Published July 1, 2025
Citation Information: J Clin Invest. 2025. https://doi.org/10.1172/JCI188530.
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Research Letter In-Press Preview Dermatology Inflammation

Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

Abstract

Authors

James G. Krueger, Mrinal K. Sarkar, Mark G. Lebwohl, Akimichi Morita, Kenneth Gordon, Rachael Bogle, Christopher Cole, Anthony Coon, Richard G. Langley, Richard B. Warren, Arash Mostaghimi, Bruce Strober, A. David Burden, Min Zheng, Aaron R. Mangold, Milan J. Anadkat, Jonathan N. Barker, Joseph F. Merola, Lam C. Tsoi, Ming Tang, Kolja Becker, Denis Delic, Christian Thoma, Johann E. Gudjonsson

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