Clonal hematopoiesis detection by simultaneous assessment of peripheral blood mononuclear cells, blood plasma, and saliva

Caitlin M. Stewart; Sonya Parpart-Li; James R. White; Mitesh Patel; Oliver Artz; Michael B. Foote; Erika Gedvilaite; Michelle F. Lamendola-Essel; Drew Gerber; Rohini Bhattacharya; Justin M. Haseltine; Kety Huberman; Kelly L. Bolton; Ross L. Levine; Luis A. Diaz, Jr.

doi:10.1172/JCI191256

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Stewart, C. in: PubMed | Google Scholar |

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Parpart-Li, S. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by White, J. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Patel, M. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Artz, O. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Foote, M. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Gedvilaite, E. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Lamendola-Essel, M. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Gerber, D. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Bhattacharya, R. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Haseltine, J. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Huberman, K. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Bolton, K. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Levine, R. in: PubMed | Google Scholar

¹SAIL, Memorial Sloan Kettering Cancer Center, New York, United States of America

²Grail, Menlo Park, United States of America

³Resphera Biosciences, Resphera Biosciences, Baltimore, United States of America

⁴Memorial Sloan-Kettering Cancer Center, New York, United States of America

⁵Memorial Sloan Kettering Cancer Center, New York, United States of America

⁶Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America

⁷Grossman School of Medicine, New York University, New York, United States of America

⁸Emory University School of Medicine, Atlanta, United States of America

⁹Eurofins, Fremont, United States of America

¹⁰Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering cancer Center, New York, United States of America

¹¹Medicine, Washington University, St. Louis, United States of America

¹²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, United States of America

Find articles by Diaz, Jr., L. in: PubMed | Google Scholar

Clonal hematopoiesis detection by simultaneous assessment of peripheral blood mononuclear cells, blood plasma, and saliva

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Clonal hematopoiesis detection by simultaneous assessment of peripheral blood mononuclear cells, blood plasma, and saliva

Caitlin M. Stewart,1 Sonya Parpart-Li,2 James R. White,3 Mitesh Patel,4 Oliver Artz,5 Michael B. Foote,6 Erika Gedvilaite,5 Michelle F. Lamendola-Essel,7 Drew Gerber,8 Rohini Bhattacharya,9 Justin M. Haseltine,5 Kety Huberman,10 Kelly L. Bolton,11 Ross L. Levine,12 and Luis A. Diaz, Jr.6

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