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Research LetterIn-Press PreviewImmunologyOncology
Open Access | 
10.1172/JCI192927
Early CD4+ T-cell proliferative burst and chronic T-cell engagement impact myeloma outcomes following T-cell engager therapy
Alyssa M. Duffy,1 Anshika Goenka,1 Maryam I. Azeem,1 Azmain Taz,1 Sayalee V. Potdar,1 Sara A. Scott,2 Ellen Marin,2 Jonathan L. Kaufman,1 Craig C. Hofmeister,1 Nisha S. Joseph,1 Vikas A. Gupta,1 Sagar Lonial,1 Ajay K. Nooka,1 Madhav V. Dhodapkar,3 and Kavita M. Dhodapkar3
1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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Potdar, S.
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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Hofmeister, C.
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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Gupta, V.
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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Nooka, A.
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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1Department of Hematology/Medical Oncology, Emory University, Atlanta, United States of America
2Emory Healthcare, Atlanta, United States of America
3Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, United States of America
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Dhodapkar, K.
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Published July 31, 2025 - More info
Copyright © 2025, Duffy et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)