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Viewpoint

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Pushing the boundaries with collision collaboration: the marriage of ideas
Jeffrey C. Rathmell, W. Kimryn Rathmell
Jeffrey C. Rathmell, W. Kimryn Rathmell
Published January 19, 2021
Citation Information: J Clin Invest. 2021;131(2):e145964. https://doi.org/10.1172/JCI145964.
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Pushing the boundaries with collision collaboration: the marriage of ideas

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Abstract

Authors

Jeffrey C. Rathmell, W. Kimryn Rathmell

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The whole is greater than the sum of the parts
Louis J. Ptáček, Ying-Hui Fu
Louis J. Ptáček, Ying-Hui Fu
Published January 19, 2021
Citation Information: J Clin Invest. 2021;131(2):e145965. https://doi.org/10.1172/JCI145965.
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The whole is greater than the sum of the parts

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Abstract

Authors

Louis J. Ptáček, Ying-Hui Fu

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It takes a village: lessons from collaborative science
E. Dale Abel
E. Dale Abel
Published January 19, 2021
Citation Information: J Clin Invest. 2021;131(2):e145962. https://doi.org/10.1172/JCI145962.
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It takes a village: lessons from collaborative science

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Abstract

Authors

E. Dale Abel

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The power of two: lessons from a scientific partnership
Robert V. Farese Jr., Tobias C. Walther
Robert V. Farese Jr., Tobias C. Walther
Published January 19, 2021
Citation Information: J Clin Invest. 2021;131(2):e145966. https://doi.org/10.1172/JCI145966.
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The power of two: lessons from a scientific partnership

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Abstract

Authors

Robert V. Farese Jr., Tobias C. Walther

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COVID-19 vaccine testing in pregnant females is necessary
Sabra L. Klein, … , Patrick S. Creisher, Irina Burd
Sabra L. Klein, … , Patrick S. Creisher, Irina Burd
Published January 14, 2021
Citation Information: J Clin Invest. 2021. https://doi.org/10.1172/JCI147553.
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COVID-19 vaccine testing in pregnant females is necessary

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Limited evidence exists regarding the use of the currently approved COVID-19 mRNA vaccines (Pfizer-BioNtech BNT162b2 and Moderna mRNA-1273) during pregnancy. In this Viewpoint, Klein et al. discuss gaps in knowledge and make recommendations to incorporate age, sex, and pregnancy in the preclinical and clincal vaccine development pipeline.

Authors

Sabra L. Klein, Patrick S. Creisher, Irina Burd

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Generating evidence for therapeutic effects: the need for well-conducted randomized trials
Robert M. Califf, … , Adrian F. Hernandez, Eric D. Peterson
Robert M. Califf, … , Adrian F. Hernandez, Eric D. Peterson
Published December 3, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI146391.
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Generating evidence for therapeutic effects: the need for well-conducted randomized trials

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In this viewpoint, Robert Califf, former commissioner of the U.S. Food and Drug Administration, and colleagues reflect on how to approach questions about which patient treatments and strategies work, particularly in light of the tremendous pressure on the government and biomedical research enterprise to quickly develop safe, effective therapies during the SARS-CoV-2 pandemic.

Authors

Robert M. Califf, Lesley H. Curtis, Robert A. Harrington, Adrian F. Hernandez, Eric D. Peterson

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The use of observational research to inform clinical practice
Nigel Paneth, Michael Joyner
Nigel Paneth, Michael Joyner
Published December 3, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI146392.
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The use of observational research to inform clinical practice

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Randomized controlled trials are the preferred design for the analysis of health-related interventions. In this Viewpoint, Nigel Paneth and Michael Joyner discuss circumstances when randomized controlled trials might not be feasible and the criteria that should be used when considering applying observational data medicine.

Authors

Nigel Paneth, Michael Joyner

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A CRISPR view of the 2020 Nobel Prize in Chemistry
Katherine E. Uyhazi, Jean Bennett
Katherine E. Uyhazi, Jean Bennett
Published November 17, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI145214.
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A CRISPR view of the 2020 Nobel Prize in Chemistry

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Katherine Uyhazi and renowned gene therapy pioneer Jean Bennett share their perspective on the 2020 Nobel Prize in Chemistry awarded to Emmanuelle Charpentier and Jennifer Doudna for their discovery of the CRISPR/Cas9 genetic scissors that have revolutionized genome editing.

Authors

Katherine E. Uyhazi, Jean Bennett

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Emergency seed funding for COVID-19 research: lessons from Johns Hopkins University
Julie Messersmith, … , Marc Lennon, Denis Wirtz
Julie Messersmith, … , Marc Lennon, Denis Wirtz
Published November 10, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI145615.
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Emergency seed funding for COVID-19 research: lessons from Johns Hopkins University

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Seed grant programs are an efficient mechanism for universities to invest in high-risk ideas, incite collaborative research, support early career faculty, and direct faculty towards a specific goal. At the outset of the COVID-19 pandemic, Johns Hopkins leadership quickly mobilized to support research teams as they pivoted to gather preliminary data and seek solutions to save lives. Here we discuss key lessons learned from the program.

Authors

Julie Messersmith, Chasmine Stoddart-Osumah, Marc Lennon, Denis Wirtz

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Getting into Good Trouble: Black Lives Matter and Black Professors Matter
Briyana R. Chisholm, … , Sherita H. Golden, Linda Resar
Briyana R. Chisholm, … , Sherita H. Golden, Linda Resar
Published November 3, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI144524.
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Getting into Good Trouble: Black Lives Matter and Black Professors Matter

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In the wake of the brutal murders of Ahmaud Arbery, Sean Reed, Breonna Taylor, and George Floyd and, amidst international outcries for social justice, many of us are asking ourselves what we can do to effect change. How can we be impactful allies in the medical profession? How can we support and protect our Black students and foster their careers? This Viewpoint examines the importance of improving diversity and inclusion among physicians and scientists at academic institutions .

Authors

Briyana R. Chisholm, Enid R. Neptune, Sherita H. Golden, Linda Resar

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