Jeffrey C. Rathmell, W. Kimryn Rathmell
Louis J. Ptáček, Ying-Hui Fu
E. Dale Abel
Robert V. Farese Jr., Tobias C. Walther
Limited evidence exists regarding the use of the currently approved COVID-19 mRNA vaccines (Pfizer-BioNtech BNT162b2 and Moderna mRNA-1273) during pregnancy. In this Viewpoint, Klein et al. discuss gaps in knowledge and make recommendations to incorporate age, sex, and pregnancy in the preclinical and clincal vaccine development pipeline.
Sabra L. Klein, Patrick S. Creisher, Irina Burd
In this viewpoint, Robert Califf, former commissioner of the U.S. Food and Drug Administration, and colleagues reflect on how to approach questions about which patient treatments and strategies work, particularly in light of the tremendous pressure on the government and biomedical research enterprise to quickly develop safe, effective therapies during the SARS-CoV-2 pandemic.
Robert M. Califf, Lesley H. Curtis, Robert A. Harrington, Adrian F. Hernandez, Eric D. Peterson
Randomized controlled trials are the preferred design for the analysis of health-related interventions. In this Viewpoint, Nigel Paneth and Michael Joyner discuss circumstances when randomized controlled trials might not be feasible and the criteria that should be used when considering applying observational data medicine.
Nigel Paneth, Michael Joyner
Katherine Uyhazi and renowned gene therapy pioneer Jean Bennett share their perspective on the 2020 Nobel Prize in Chemistry awarded to Emmanuelle Charpentier and Jennifer Doudna for their discovery of the CRISPR/Cas9 genetic scissors that have revolutionized genome editing.
Katherine E. Uyhazi, Jean Bennett
Seed grant programs are an efficient mechanism for universities to invest in high-risk ideas, incite collaborative research, support early career faculty, and direct faculty towards a specific goal. At the outset of the COVID-19 pandemic, Johns Hopkins leadership quickly mobilized to support research teams as they pivoted to gather preliminary data and seek solutions to save lives. Here we discuss key lessons learned from the program.
Julie Messersmith, Chasmine Stoddart-Osumah, Marc Lennon, Denis Wirtz
In the wake of the brutal murders of Ahmaud Arbery, Sean Reed, Breonna Taylor, and George Floyd and, amidst international outcries for social justice, many of us are asking ourselves what we can do to effect change. How can we be impactful allies in the medical profession? How can we support and protect our Black students and foster their careers? This Viewpoint examines the importance of improving diversity and inclusion among physicians and scientists at academic institutions .
Briyana R. Chisholm, Enid R. Neptune, Sherita H. Golden, Linda Resar
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