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Abstract
Authors
Jeffrey A. Bluestone
Figure 1
The 2025 Nobel Prize in Physiology or Medicine recognizes work by Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi identifying the critical functions of Tregs in maintaining central tolerance.
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(A ) The relatively small population of Tregs employs diverse mechanisms to maintain tolerance and fine-tune inflammatory responses. (B ) The discovery of Tregs formed the basis for Treg-targeted therapeutic approaches for a wide range of conditions.
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ISSN: 0021-9738 (print), 1558-8238 (online)