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Issue published October 1, 1997 Previous issue | Next issue

  • Volume 100, Issue 7
Go to section:
  • Research Articles
Research Articles
Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin.
M M Teixeira, … , T J Williams, P G Hellewell
M M Teixeira, … , T J Williams, P G Hellewell
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1657-1666. https://doi.org/10.1172/JCI119690.
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Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin.

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Research Article

Authors

M M Teixeira, T N Wells, N W Lukacs, A E Proudfoot, S L Kunkel, T J Williams, P G Hellewell

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Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.
M Fischer, … , U Klein, R Küppers
M Fischer, … , U Klein, R Küppers
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1667-1676. https://doi.org/10.1172/JCI119691.
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Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.

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Research Article

Authors

M Fischer, U Klein, R Küppers

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Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.
K Yasui, … , K Agematsu, A Komiyama
K Yasui, … , K Agematsu, A Komiyama
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1677-1684. https://doi.org/10.1172/JCI119692.
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Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.

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Research Article

Authors

K Yasui, B Hu, T Nakazawa, K Agematsu, A Komiyama

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Glucose-specific regulation of aldose reductase in capan-1 human pancreatic duct cells In vitro.
J V Busik, … , C A Greenidge, D N Henry
J V Busik, … , C A Greenidge, D N Henry
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1685-1692. https://doi.org/10.1172/JCI119693.
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Glucose-specific regulation of aldose reductase in capan-1 human pancreatic duct cells In vitro.

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Research Article

Authors

J V Busik, S R Hootman, C A Greenidge, D N Henry

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Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene.
L J Bruce, … , O Wrong, M J Tanner
L J Bruce, … , O Wrong, M J Tanner
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1693-1707. https://doi.org/10.1172/JCI119694.
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Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene.

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Research Article

Authors

L J Bruce, D L Cope, G K Jones, A E Schofield, M Burley, S Povey, R J Unwin, O Wrong, M J Tanner

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A chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo.
K Okuda, … , R A Etten, J D Griffin
K Okuda, … , R A Etten, J D Griffin
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1708-1715. https://doi.org/10.1172/JCI119695.
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A chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo.

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Research Article

Authors

K Okuda, A D'Andrea, R A Etten, J D Griffin

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1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production.
S Peleg, … , M Talpaz, Z Estrov
S Peleg, … , M Talpaz, Z Estrov
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1716-1724. https://doi.org/10.1172/JCI119696.
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1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production.

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Research Article

Authors

S Peleg, H Qiu, S Reddy, D Harris, Q Van, E H Estey, M Talpaz, Z Estrov

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Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.
T W Kuijpers, … , A J Verhoeven, D Roos
T W Kuijpers, … , A J Verhoeven, D Roos
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1725-1733. https://doi.org/10.1172/JCI119697.
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Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.

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Research Article

Authors

T W Kuijpers, R A Van Lier, D Hamann, M de Boer, L Y Thung, R S Weening, A J Verhoeven, D Roos

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Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.
E Chaves-Olarte, … , C Eichel-Streiber, M Thelestam
E Chaves-Olarte, … , C Eichel-Streiber, M Thelestam
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1734-1741. https://doi.org/10.1172/JCI119698.
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Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.

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Research Article

Authors

E Chaves-Olarte, M Weidmann, C Eichel-Streiber, M Thelestam

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Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy. Association with increased sarcoplasmic reticulum Ca2+-ATPase and alpha-myosin heavy chain in rat hearts.
K C Chang, … , P C Simpson, S A Camacho
K C Chang, … , P C Simpson, S A Camacho
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1742-1749. https://doi.org/10.1172/JCI119699.
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Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy. Association with increased sarcoplasmic reticulum Ca2+-ATPase and alpha-myosin heavy chain in rat hearts.

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Research Article

Authors

K C Chang, V M Figueredo, J H Schreur, K Kariya, M W Weiner, P C Simpson, S A Camacho

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Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.
M Shimabukuro, … , Y Lee, R H Unger
M Shimabukuro, … , Y Lee, R H Unger
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1750-1754. https://doi.org/10.1172/JCI119700.
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Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.

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Authors

M Shimabukuro, K Koyama, Y Lee, R H Unger

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Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens.
C W Slemenda, … , M Peacock, C C Johnston
C W Slemenda, … , M Peacock, C C Johnston
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1755-1759. https://doi.org/10.1172/JCI119701.
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Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens.

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Research Article

Authors

C W Slemenda, C Longcope, L Zhou, S L Hui, M Peacock, C C Johnston

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Nitric oxide inhibition of coxsackievirus replication in vitro.
C Zaragoza, … , A McMillan, C J Lowenstein
C Zaragoza, … , A McMillan, C J Lowenstein
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1760-1767. https://doi.org/10.1172/JCI119702.
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Nitric oxide inhibition of coxsackievirus replication in vitro.

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Research Article

Authors

C Zaragoza, C J Ocampo, M Saura, A McMillan, C J Lowenstein

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Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.
S P Burns, … , T C Going, R A Bailey
S P Burns, … , T C Going, R A Bailey
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1768-1774. https://doi.org/10.1172/JCI119703.
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Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.

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Research Article

Authors

S P Burns, M Desai, R D Cohen, C N Hales, R A Iles, J P Germain, T C Going, R A Bailey

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Glucose turnover and gluconeogenesis in human pregnancy.
S Kalhan, … , E Burkett, A O'Brien
S Kalhan, … , E Burkett, A O'Brien
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1775-1781. https://doi.org/10.1172/JCI119704.
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Glucose turnover and gluconeogenesis in human pregnancy.

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Research Article

Authors

S Kalhan, K Rossi, L Gruca, E Burkett, A O'Brien

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Mechanism of hypoxic K loss in rabbit ventricle.
K Shivkumar, … , J I Goldhaber, J N Weiss
K Shivkumar, … , J I Goldhaber, J N Weiss
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1782-1788. https://doi.org/10.1172/JCI119705.
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Mechanism of hypoxic K loss in rabbit ventricle.

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Research Article

Authors

K Shivkumar, N A Deutsch, S T Lamp, K Khuu, J I Goldhaber, J N Weiss

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Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex.
R M Clancy, … , M Philips, S B Abramson
R M Clancy, … , M Philips, S B Abramson
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1789-1796. https://doi.org/10.1172/JCI119706.
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Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex.

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Research Article

Authors

R M Clancy, J Rediske, X Tang, N Nijher, S Frenkel, M Philips, S B Abramson

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Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.
N Franchimont, … , S Rydziel, E Canalis
N Franchimont, … , S Rydziel, E Canalis
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1797-1803. https://doi.org/10.1172/JCI119707.
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Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.

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Research Article

Authors

N Franchimont, S Rydziel, E Canalis

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Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.
D Wu, … , J Yang, W M Pardridge
D Wu, … , J Yang, W M Pardridge
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1804-1812. https://doi.org/10.1172/JCI119708.
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Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.

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Abstract

Research Article

Authors

D Wu, J Yang, W M Pardridge

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Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.
R Aikawa, … , Y Hiroi, Y Yazaki
R Aikawa, … , Y Hiroi, Y Yazaki
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1813-1821. https://doi.org/10.1172/JCI119709.
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Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

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Research Article

Authors

R Aikawa, I Komuro, T Yamazaki, Y Zou, S Kudoh, M Tanaka, I Shiojima, Y Hiroi, Y Yazaki

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Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus.
K Tanaka, … , N Fukuyama, Y Koga
K Tanaka, … , N Fukuyama, Y Koga
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1822-1830. https://doi.org/10.1172/JCI119710.
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Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus.

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Research Article

Authors

K Tanaka, H Nakazawa, K Okada, K Umezawa, N Fukuyama, Y Koga

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Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.
L Rossetti, … , E B Katz, M J Charron
L Rossetti, … , E B Katz, M J Charron
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1831-1839. https://doi.org/10.1172/JCI119711.
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Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.

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Research Article

Authors

L Rossetti, A E Stenbit, W Chen, M Hu, N Barzilai, E B Katz, M J Charron

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Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.
Y Kajimoto, … , J Miyazaki, Y Yamasaki
Y Kajimoto, … , J Miyazaki, Y Yamasaki
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1840-1846. https://doi.org/10.1172/JCI119712.
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Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.

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Research Article

Authors

Y Kajimoto, H Watada, T a Matsuoka, H Kaneto, Y Fujitani, J Miyazaki, Y Yamasaki

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Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.
L De Franceschi, … , Y Beuzard, C Brugnara
L De Franceschi, … , Y Beuzard, C Brugnara
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1847-1852. https://doi.org/10.1172/JCI119713.
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Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.

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Research Article

Authors

L De Franceschi, D Bachir, F Galacteros, G Tchernia, T Cynober, S Alper, O Platt, Y Beuzard, C Brugnara

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Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis.
A S Gukovskaya, … , S Gukovsky, S J Pandol
A S Gukovskaya, … , S Gukovsky, S J Pandol
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1853-1862. https://doi.org/10.1172/JCI119714.
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Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis.

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Research Article

Authors

A S Gukovskaya, I Gukovsky, V Zaninovic, M Song, D Sandoval, S Gukovsky, S J Pandol

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Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
P Peraldi, … , M Xu, B M Spiegelman
P Peraldi, … , M Xu, B M Spiegelman
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1863-1869. https://doi.org/10.1172/JCI119715.
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Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

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Authors

P Peraldi, M Xu, B M Spiegelman

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Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.
P H Vachon, … , U M Wewer, E Engvall
P H Vachon, … , U M Wewer, E Engvall
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1870-1881. https://doi.org/10.1172/JCI119716.
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Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.

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Research Article

Authors

P H Vachon, H Xu, L Liu, F Loechel, Y Hayashi, K Arahata, J C Reed, U M Wewer, E Engvall

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Entrainment of the diurnal rhythm of plasma leptin to meal timing.
D A Schoeller, … , M K Sinha, J F Caro
D A Schoeller, … , M K Sinha, J F Caro
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1882-1887. https://doi.org/10.1172/JCI119717.
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Entrainment of the diurnal rhythm of plasma leptin to meal timing.

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Research Article

Authors

D A Schoeller, L K Cella, M K Sinha, J F Caro

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Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.
C Kane, … , A Aynsley-Green, M J Dunne
C Kane, … , A Aynsley-Green, M J Dunne
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1888-1893. https://doi.org/10.1172/JCI119718.
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Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.

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Research Article

Authors

C Kane, K J Lindley, P R Johnson, R F James, P J Milla, A Aynsley-Green, M J Dunne

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Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.
T D Batiuk, … , L Kung, P F Halloran
T D Batiuk, … , L Kung, P F Halloran
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1894-1901. https://doi.org/10.1172/JCI119719.
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Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.

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Research Article

Authors

T D Batiuk, L Kung, P F Halloran

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