The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights
J. Wesley Pike, Mark B. Meyer, Seong-Min Lee, Melda Onal, and Nancy A. Benkusky
Department of Biochemistry, University of Wisconsin — Madison, Madison, Wisconsin, USA.
Address correspondence to: J. Wesley Pike, Department of Biochemistry, University of Wisconsin-Madison, Biochem Addition, Room 543D, 433 Babcock Drive, Madison, Wisconsin 53706, USA. Phone: 608.262.8229; E-mail: pike@biochem.wisc.edu.
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Department of Biochemistry, University of Wisconsin — Madison, Madison, Wisconsin, USA.
Address correspondence to: J. Wesley Pike, Department of Biochemistry, University of Wisconsin-Madison, Biochem Addition, Room 543D, 433 Babcock Drive, Madison, Wisconsin 53706, USA. Phone: 608.262.8229; E-mail: pike@biochem.wisc.edu.
Find articles by Meyer, M. in: JCI | PubMed | Google Scholar
Department of Biochemistry, University of Wisconsin — Madison, Madison, Wisconsin, USA.
Address correspondence to: J. Wesley Pike, Department of Biochemistry, University of Wisconsin-Madison, Biochem Addition, Room 543D, 433 Babcock Drive, Madison, Wisconsin 53706, USA. Phone: 608.262.8229; E-mail: pike@biochem.wisc.edu.
Find articles by Lee, S. in: JCI | PubMed | Google Scholar
Department of Biochemistry, University of Wisconsin — Madison, Madison, Wisconsin, USA.
Address correspondence to: J. Wesley Pike, Department of Biochemistry, University of Wisconsin-Madison, Biochem Addition, Room 543D, 433 Babcock Drive, Madison, Wisconsin 53706, USA. Phone: 608.262.8229; E-mail: pike@biochem.wisc.edu.
Find articles by Onal, M. in: JCI | PubMed | Google Scholar
Department of Biochemistry, University of Wisconsin — Madison, Madison, Wisconsin, USA.
Address correspondence to: J. Wesley Pike, Department of Biochemistry, University of Wisconsin-Madison, Biochem Addition, Room 543D, 433 Babcock Drive, Madison, Wisconsin 53706, USA. Phone: 608.262.8229; E-mail: pike@biochem.wisc.edu.
Find articles by Benkusky, N. in: JCI | PubMed | Google Scholar
First published February 27, 2017 - More info
J Clin Invest. 2017;127(4):1146–1154. doi:10.1172/JCI88887.
Copyright © 2017, American Society for Clinical Investigation
The vitamin D receptor (VDR) is the single known regulatory mediator of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in higher vertebrates. It acts in the nucleus of vitamin D target cells to regulate the expression of genes whose products control diverse, cell type–specific biological functions that include mineral homeostasis. In this Review we describe progress that has been made in defining new cellular sites of action of this receptor, the mechanisms through which this mediator controls the expression of genes, the biology that ensues, and the translational impact of this receptor on human health and disease. We conclude with a brief discussion of what comes next in understanding vitamin D biology and the mechanisms that underlie its actions.
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ISSN: 0021-9738 (print), 1558-8238 (online)