Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease?
In contrast to hepatocytes, which constitute over 90% of liver mass and exhibit little or no
VDR expression, VDR is highly expressed in the nonparenchymal cells of the liver. Kupffer
cells (KCs), sinusoidal endothelial cells and especially hepatic stellate cells (HSCs)[3], all
express VDR. In regards to chronic liver diseases, HSCs are the major effector cells in the
wound healing process leading to liver fibrosis, being the predominant source of both
normal and pathological hepatic extracellular
VDR expression, VDR is highly expressed in the nonparenchymal cells of the liver. Kupffer
cells (KCs), sinusoidal endothelial cells and especially hepatic stellate cells (HSCs)[3], all
express VDR. In regards to chronic liver diseases, HSCs are the major effector cells in the
wound healing process leading to liver fibrosis, being the predominant source of both
normal and pathological hepatic extracellular
In contrast to hepatocytes, which constitute over 90% of liver mass and exhibit little or no VDR expression, VDR is highly expressed in the nonparenchymal cells of the liver. Kupffer cells (KCs), sinusoidal endothelial cells and especially hepatic stellate cells (HSCs)[3], all express VDR. In regards to chronic liver diseases, HSCs are the major effector cells in the wound healing process leading to liver fibrosis, being the predominant source of both normal and pathological hepatic extracellular
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