[HTML][HTML] Genomic determinants of gene regulation by 1, 25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation*♦
MB Meyer, NA Benkusky, CH Lee, JW Pike - Journal of Biological …, 2014 - ASBMB
The biological effects of 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) on osteoblast
differentiation and function differ significantly depending upon the cellular state of
maturation. To explore this phenomenon mechanistically, we examined the impact of 1, 25
(OH) 2 D 3 on the transcriptomes of both pre-osteoblastic (POBs) and differentiated
osteoblastic (OBs) MC3T3-E1 cells, and assessed localization of the vitamin D receptor
(VDR) at sites of action on a genome-scale using ChIP sequence analysis. We observed …
differentiation and function differ significantly depending upon the cellular state of
maturation. To explore this phenomenon mechanistically, we examined the impact of 1, 25
(OH) 2 D 3 on the transcriptomes of both pre-osteoblastic (POBs) and differentiated
osteoblastic (OBs) MC3T3-E1 cells, and assessed localization of the vitamin D receptor
(VDR) at sites of action on a genome-scale using ChIP sequence analysis. We observed …