[HTML][HTML] Inactivation of the 25-hydroxyvitamin D 1α-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin …
DK Panda, D Miao, I Bolivar, J Li, R Huo… - Journal of Biological …, 2004 - ASBMB
We employed a genetic approach to determine whether deficiency of 1, 25-dihydroxyvitamin
D (1, 25 (OH) 2 D) and deficiency of the vitamin D receptor (VDR) produce the same
alterations in skeletal and calcium homeostasis and whether calcium can subserve the
skeletal functions of 1, 25 (OH) 2 D and the VDR. Mice with targeted deletion of the 25-
hydroxyvitamin D 1α-hydroxylase (1α (OH) ase-/-) gene, the VDR gene, and both genes
were exposed to 1) a high calcium intake, which maintained fertility but left mice …
D (1, 25 (OH) 2 D) and deficiency of the vitamin D receptor (VDR) produce the same
alterations in skeletal and calcium homeostasis and whether calcium can subserve the
skeletal functions of 1, 25 (OH) 2 D and the VDR. Mice with targeted deletion of the 25-
hydroxyvitamin D 1α-hydroxylase (1α (OH) ase-/-) gene, the VDR gene, and both genes
were exposed to 1) a high calcium intake, which maintained fertility but left mice …