[HTML][HTML] A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1α, 25-dihydroxyvitamin D3
MB Meyer, PD Goetsch, JW Pike - Journal of Biological Chemistry, 2010 - ASBMB
CYP24A1 expression is up-regulated by 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) via a
vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D
response elements (VDREs) located near the proximal promoter. Interestingly, although 1,
25 (OH) 2 D 3 induced VDR/RXR binding to the VDRE-containing proximal promoter, the
VDR/RXR heterodimer also localized to a cluster of at least four potential enhancers located
in intergenic regions 50–69 kb downstream of the human CYP24A1 gene and 35–45 kb …
vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D
response elements (VDREs) located near the proximal promoter. Interestingly, although 1,
25 (OH) 2 D 3 induced VDR/RXR binding to the VDRE-containing proximal promoter, the
VDR/RXR heterodimer also localized to a cluster of at least four potential enhancers located
in intergenic regions 50–69 kb downstream of the human CYP24A1 gene and 35–45 kb …