[HTML][HTML] Selective distal enhancer control of the Mmp13 gene identified through clustered regularly interspaced short palindromic repeat (CRISPR) genomic deletions
MB Meyer, NA Benkusky, JW Pike - Journal of Biological Chemistry, 2015 - ASBMB
Matrix metalloproteinase 13 (Mmp13, collagenase-3) plays an essential role in bone
metabolism and mineral homeostasis. It is regulated by numerous factors, including BMP-2,
parathyroid hormone, and 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), through
transcription factors such as Runt-related transcription factor 2 (RUNX2), CCAAT/enhancer-
binding protein β (C/EBPβ), OSX, and vitamin D receptor (VDR). During osteoblast
maturation, the basal expression of Mmp13 and its sensitivity to 1, 25 (OH) 2 D 3 are …
metabolism and mineral homeostasis. It is regulated by numerous factors, including BMP-2,
parathyroid hormone, and 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), through
transcription factors such as Runt-related transcription factor 2 (RUNX2), CCAAT/enhancer-
binding protein β (C/EBPβ), OSX, and vitamin D receptor (VDR). During osteoblast
maturation, the basal expression of Mmp13 and its sensitivity to 1, 25 (OH) 2 D 3 are …