Issue published December 1, 2002 Previous issue | Next issue

  • Volume 110, Issue 11
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In This Issue

Abstract

Authors

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Perspectives
Liver injury in α1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury
David H. Perlmutter
David H. Perlmutter
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α1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy
David A. Lomas, Ravi Mahadeva
David A. Lomas, Ravi Mahadeva
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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis
Marina S. Gelman, Ron R. Kopito
Marina S. Gelman, Ron R. Kopito
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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis

Abstract

Perspective

Authors

Marina S. Gelman, Ron R. Kopito

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Commentaries
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors
Qais Al-Awqati
Qais Al-Awqati
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Neutrophils and lung injury: getting it right
Thomas R. Martin
Thomas R. Martin
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Neutrophils and lung injury: getting it right

Abstract

Commentary

Authors

Thomas R. Martin

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Fatty acid oxidation in human skeletal muscle
Michael D. Jensen
Michael D. Jensen
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Fatty acid oxidation in human skeletal muscle

Abstract

Commentary

Authors

Michael D. Jensen

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Fatal attraction: chemokines and type 1 diabetes
Mark A. Atkinson, S. Brian Wilson
Mark A. Atkinson, S. Brian Wilson
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Fatal attraction: chemokines and type 1 diabetes

Abstract

Commentary

Authors

Mark A. Atkinson, S. Brian Wilson

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Getting Tie(2)d up in angiogenesis
Markus Ramsauer, Patricia A. D’Amore
Markus Ramsauer, Patricia A. D’Amore
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Getting Tie(2)d up in angiogenesis

Abstract

Commentary

Authors

Markus Ramsauer, Patricia A. D’Amore

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Research Articles
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa
Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa
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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

Abstract

Research Article

Authors

Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa

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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis
Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin
Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin
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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis

Abstract

Research Article

Authors

Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin

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Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
M. Neale Weitzmann, Cristiana Roggia, Gianluca Toraldo, Louise Weitzmann, Roberto Pacifici
M. Neale Weitzmann, Cristiana Roggia, Gianluca Toraldo, Louise Weitzmann, Roberto Pacifici
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Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency

Abstract

Research Article

Authors

M. Neale Weitzmann, Cristiana Roggia, Gianluca Toraldo, Louise Weitzmann, Roberto Pacifici

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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion
Tonghui Ma, Jay R. Thiagarajah, Hong Yang, Nitin D. Sonawane, Chiara Folli, Luis J.V. Galietta, A.S. Verkman
Tonghui Ma, Jay R. Thiagarajah, Hong Yang, Nitin D. Sonawane, Chiara Folli, Luis J.V. Galietta, A.S. Verkman
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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Abstract

Research Article

Authors

Tonghui Ma, Jay R. Thiagarajah, Hong Yang, Nitin D. Sonawane, Chiara Folli, Luis J.V. Galietta, A.S. Verkman

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NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele
Hiroyasu Tsukaguchi, Akulapalli Sudhakar, Tu Cam Le, Trang Nguyen, Jun Yao, Joshua A. Schwimmer, Asher D. Schachter, Esteban Poch, Patricia F. Abreu, Gerald B. Appel, Aparecido B. Pereira, Raghu Kalluri, Martin R. Pollak
Hiroyasu Tsukaguchi, Akulapalli Sudhakar, Tu Cam Le, Trang Nguyen, Jun Yao, Joshua A. Schwimmer, Asher D. Schachter, Esteban Poch, Patricia F. Abreu, Gerald B. Appel, Aparecido B. Pereira, Raghu Kalluri, Martin R. Pollak
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NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele

Abstract

Research Article

Authors

Hiroyasu Tsukaguchi, Akulapalli Sudhakar, Tu Cam Le, Trang Nguyen, Jun Yao, Joshua A. Schwimmer, Asher D. Schachter, Esteban Poch, Patricia F. Abreu, Gerald B. Appel, Aparecido B. Pereira, Raghu Kalluri, Martin R. Pollak

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A monoclonal thyroid-stimulating antibody
Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies
Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies
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A monoclonal thyroid-stimulating antibody

Abstract

Research Article

Authors

Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies

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CCR4-bearing T cells participate in autoimmune diabetes
Soon H. Kim, Mary M. Cleary, Howard S. Fox, David Chantry, Nora Sarvetnick
Soon H. Kim, Mary M. Cleary, Howard S. Fox, David Chantry, Nora Sarvetnick
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CCR4-bearing T cells participate in autoimmune diabetes

Abstract

Research Article

Authors

Soon H. Kim, Mary M. Cleary, Howard S. Fox, David Chantry, Nora Sarvetnick

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Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
Blake B. Rasmussen, Ulf C. Holmbäck, Elena Volpi, Beatrice Morio-Liondore, Douglas Paddon-Jones, Robert R. Wolfe
Blake B. Rasmussen, Ulf C. Holmbäck, Elena Volpi, Beatrice Morio-Liondore, Douglas Paddon-Jones, Robert R. Wolfe
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Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle

Abstract

Research Article

Authors

Blake B. Rasmussen, Ulf C. Holmbäck, Elena Volpi, Beatrice Morio-Liondore, Douglas Paddon-Jones, Robert R. Wolfe

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Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1
Emily R. Eden, Dilipkumar D. Patel, Xi-Ming Sun, Jemima J. Burden, Michael Themis, Matthew Edwards, Philip Lee, Clare Neuwirth, Rossitza P. Naoumova, Anne K. Soutar
Emily R. Eden, Dilipkumar D. Patel, Xi-Ming Sun, Jemima J. Burden, Michael Themis, Matthew Edwards, Philip Lee, Clare Neuwirth, Rossitza P. Naoumova, Anne K. Soutar
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Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1

Abstract

Research Article

Authors

Emily R. Eden, Dilipkumar D. Patel, Xi-Ming Sun, Jemima J. Burden, Michael Themis, Matthew Edwards, Philip Lee, Clare Neuwirth, Rossitza P. Naoumova, Anne K. Soutar

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Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
John A. Belperio, Michael P. Keane, Marie D. Burdick, Vedang Londhe, Ying Ying Xue, Kewang Li, Roderick J. Phillips, Robert M. Strieter
John A. Belperio, Michael P. Keane, Marie D. Burdick, Vedang Londhe, Ying Ying Xue, Kewang Li, Roderick J. Phillips, Robert M. Strieter
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Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury

Abstract

Research Article

Authors

John A. Belperio, Michael P. Keane, Marie D. Burdick, Vedang Londhe, Ying Ying Xue, Kewang Li, Roderick J. Phillips, Robert M. Strieter

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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
Dimitri Lodygin, Antje Menssen, Heiko Hermeking
Dimitri Lodygin, Antje Menssen, Heiko Hermeking
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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

Abstract

Research Article

Authors

Dimitri Lodygin, Antje Menssen, Heiko Hermeking

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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
Florian P. Limbourg, Zhihong Huang, Jean-Christophe Plumier, Tommaso Simoncini, Masayuki Fujioka, Jan Tuckermann, Günther Schütz, Michael A. Moskowitz, James K. Liao
Florian P. Limbourg, Zhihong Huang, Jean-Christophe Plumier, Tommaso Simoncini, Masayuki Fujioka, Jan Tuckermann, Günther Schütz, Michael A. Moskowitz, James K. Liao
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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Abstract

Research Article

Authors

Florian P. Limbourg, Zhihong Huang, Jean-Christophe Plumier, Tommaso Simoncini, Masayuki Fujioka, Jan Tuckermann, Günther Schütz, Michael A. Moskowitz, James K. Liao

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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett
Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett
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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase

Abstract

Research Article

Authors

Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett

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