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  • Volume 110, Issue 11 , Pages 1577-1747
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In This Issue
/articles/view/119963
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1577-1577. https://doi.org/10.1172/JCI119963.
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In This Issue

Abstract

Authors

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Perspectives
Liver injury in α1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury
David H. Perlmutter
David H. Perlmutter
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1579-1583. https://doi.org/10.1172/JCI16787.
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α1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy
David A. Lomas, Ravi Mahadeva
David A. Lomas, Ravi Mahadeva
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1585-1590. https://doi.org/10.1172/JCI16782.
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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis
Marina S. Gelman, Ron R. Kopito
Marina S. Gelman, Ron R. Kopito
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1591-1597. https://doi.org/10.1172/JCI16786.
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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis

Abstract

Perspective

Authors

Marina S. Gelman, Ron R. Kopito

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Commentaries
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors
Qais Al-Awqati
Qais Al-Awqati
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1599-1601. https://doi.org/10.1172/JCI17301.
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Neutrophils and lung injury: getting it right
Thomas R. Martin
Thomas R. Martin
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1603-1605. https://doi.org/10.1172/JCI17302.
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Neutrophils and lung injury: getting it right

Abstract

Commentary

Authors

Thomas R. Martin

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Fatty acid oxidation in human skeletal muscle
Michael D. Jensen
Michael D. Jensen
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1607-1609. https://doi.org/10.1172/JCI17303.
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Fatty acid oxidation in human skeletal muscle

Abstract

Commentary

Authors

Michael D. Jensen

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Fatal attraction: chemokines and type 1 diabetes
Mark A. Atkinson, S. Brian Wilson
Mark A. Atkinson, S. Brian Wilson
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1611-1613. https://doi.org/10.1172/JCI17311.
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Fatal attraction: chemokines and type 1 diabetes

Abstract

Commentary

Authors

Mark A. Atkinson, S. Brian Wilson

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Getting Tie(2)d up in angiogenesis
Markus Ramsauer, Patricia A. D’Amore
Markus Ramsauer, Patricia A. D’Amore
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1615-1617. https://doi.org/10.1172/JCI17326.
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Getting Tie(2)d up in angiogenesis

Abstract

Commentary

Authors

Markus Ramsauer, Patricia A. D’Amore

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Research Articles
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Akiyoshi Uemura, … , George D. Yancopoulos, Shin-Ichi Nishikawa
Akiyoshi Uemura, … , George D. Yancopoulos, Shin-Ichi Nishikawa
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1619-1628. https://doi.org/10.1172/JCI15621.
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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

Abstract

Research Article

Authors

Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa

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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis
Christine Fritsch, … , Marc S. Levin, Deborah C. Rubin
Christine Fritsch, … , Marc S. Levin, Deborah C. Rubin
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1629-1641. https://doi.org/10.1172/JCI13588.
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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis

Abstract

Research Article

Authors

Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin

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Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
M. Neale Weitzmann, … , Louise Weitzmann, Roberto Pacifici
M. Neale Weitzmann, … , Louise Weitzmann, Roberto Pacifici
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1643-1650. https://doi.org/10.1172/JCI15687.
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Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency

Abstract

Research Article

Authors

M. Neale Weitzmann, Cristiana Roggia, Gianluca Toraldo, Louise Weitzmann, Roberto Pacifici

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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion
Tonghui Ma, … , Luis J.V. Galietta, A.S. Verkman
Tonghui Ma, … , Luis J.V. Galietta, A.S. Verkman
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1651-1658. https://doi.org/10.1172/JCI16112.
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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Abstract

Research Article

Authors

Tonghui Ma, Jay R. Thiagarajah, Hong Yang, Nitin D. Sonawane, Chiara Folli, Luis J.V. Galietta, A.S. Verkman

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NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele
Hiroyasu Tsukaguchi, … , Raghu Kalluri, Martin R. Pollak
Hiroyasu Tsukaguchi, … , Raghu Kalluri, Martin R. Pollak
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1659-1666. https://doi.org/10.1172/JCI16242.
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NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele

Abstract

Research Article

Authors

Hiroyasu Tsukaguchi, Akulapalli Sudhakar, Tu Cam Le, Trang Nguyen, Jun Yao, Joshua A. Schwimmer, Asher D. Schachter, Esteban Poch, Patricia F. Abreu, Gerald B. Appel, Aparecido B. Pereira, Raghu Kalluri, Martin R. Pollak

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A monoclonal thyroid-stimulating antibody
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Takao Ando, … , Yuji Nagayama, Terry F. Davies
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1667-1674. https://doi.org/10.1172/JCI16991.
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A monoclonal thyroid-stimulating antibody

Abstract

Research Article

Authors

Takao Ando, Rauf Latif, Alla Pritsker, Thomas Moran, Yuji Nagayama, Terry F. Davies

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CCR4-bearing T cells participate in autoimmune diabetes
Soon H. Kim, … , David Chantry, Nora Sarvetnick
Soon H. Kim, … , David Chantry, Nora Sarvetnick
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1675-1686. https://doi.org/10.1172/JCI15547.
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CCR4-bearing T cells participate in autoimmune diabetes

Abstract

Research Article

Authors

Soon H. Kim, Mary M. Cleary, Howard S. Fox, David Chantry, Nora Sarvetnick

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Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
Blake B. Rasmussen, … , Douglas Paddon-Jones, Robert R. Wolfe
Blake B. Rasmussen, … , Douglas Paddon-Jones, Robert R. Wolfe
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1687-1693. https://doi.org/10.1172/JCI15715.
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Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle

Abstract

Research Article

Authors

Blake B. Rasmussen, Ulf C. Holmbäck, Elena Volpi, Beatrice Morio-Liondore, Douglas Paddon-Jones, Robert R. Wolfe

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Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1
Emily R. Eden, … , Rossitza P. Naoumova, Anne K. Soutar
Emily R. Eden, … , Rossitza P. Naoumova, Anne K. Soutar
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1695-1702. https://doi.org/10.1172/JCI16445.
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Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1

Abstract

Research Article

Authors

Emily R. Eden, Dilipkumar D. Patel, Xi-Ming Sun, Jemima J. Burden, Michael Themis, Matthew Edwards, Philip Lee, Clare Neuwirth, Rossitza P. Naoumova, Anne K. Soutar

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Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
John A. Belperio, … , Roderick J. Phillips, Robert M. Strieter
John A. Belperio, … , Roderick J. Phillips, Robert M. Strieter
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1703-1716. https://doi.org/10.1172/JCI15849.
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Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury

Abstract

Research Article

Authors

John A. Belperio, Michael P. Keane, Marie D. Burdick, Vedang Londhe, Ying Ying Xue, Kewang Li, Roderick J. Phillips, Robert M. Strieter

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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
Dimitri Lodygin, … , Antje Menssen, Heiko Hermeking
Dimitri Lodygin, … , Antje Menssen, Heiko Hermeking
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1717-1727. https://doi.org/10.1172/JCI16588.
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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

Abstract

Research Article

Authors

Dimitri Lodygin, Antje Menssen, Heiko Hermeking

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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
Florian P. Limbourg, … , Michael A. Moskowitz, James K. Liao
Florian P. Limbourg, … , Michael A. Moskowitz, James K. Liao
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1729-1738. https://doi.org/10.1172/JCI15481.
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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids

Abstract

Research Article

Authors

Florian P. Limbourg, Zhihong Huang, Jean-Christophe Plumier, Tommaso Simoncini, Masayuki Fujioka, Jan Tuckermann, Günther Schütz, Michael A. Moskowitz, James K. Liao

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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1739-1747. https://doi.org/10.1172/JCI15695.
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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase

Abstract

Research Article

Authors

Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett

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