Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis

¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, United States of America

²Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America

³Glychotechnology Research and Training Center, University of California San Diego, La Jolla, United States of America

⁴Department of Medicine, University of California San Diego, La Jolla, United States of America

⁵Department of Chemistry, University of California-Davis, Davis, United States of America

⁶Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canada

⁷Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

⁸Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States of America

⁹Department of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

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