[HTML][HTML] A mouse model for dietary xenosialitis: antibodies to xenoglycan can reduce fertility

F Ma, L Deng, P Secrest, L Shi, J Zhao… - Journal of Biological …, 2016 - ASBMB
Humans can incorporate the xenoglycan N-glycolylneuraminic acid (Neu5Gc) from the diet
into reproductive tissues and secretions. Most humans also have circulating antibodies
specific for this dietary xenoglycan. The potential for inflammation induced by incorporated
Neu5Gc and circulating anti-Neu5Gc antibodies, termed xenosialitis, has been discussed as
a factor influencing several human diseases. Potential effects of xenosialitis on human
fertility remain unknown. Here, we investigate possible adverse effects of the presence of …