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Central role of the P2Y12 receptor in platelet activation
Robert T. Dorsam, Satya P. Kunapuli
Robert T. Dorsam, Satya P. Kunapuli
Published February 1, 2004
Citation Information: J Clin Invest. 2004;113(3):340-345. https://doi.org/10.1172/JCI20986.
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Central role of the P2Y12 receptor in platelet activation

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Abstract

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y12 receptor antagonists that have proven therapeutic value.

Authors

Robert T. Dorsam, Satya P. Kunapuli

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VEGF: a critical player in neurodegeneration
Erik Storkebaum, Peter Carmeliet
Erik Storkebaum, Peter Carmeliet
Published January 1, 2004
Citation Information: J Clin Invest. 2004;113(1):14-18. https://doi.org/10.1172/JCI20682.
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VEGF: a critical player in neurodegeneration

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Abstract

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.

Authors

Erik Storkebaum, Peter Carmeliet

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Epithelial-mesenchymal transition and its implications for fibrosis
Raghu Kalluri, Eric G. Neilson
Raghu Kalluri, Eric G. Neilson
Published December 15, 2003
Citation Information: J Clin Invest. 2003;112(12):1776-1784. https://doi.org/10.1172/JCI20530.
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Epithelial-mesenchymal transition and its implications for fibrosis

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Abstract

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.

Authors

Raghu Kalluri, Eric G. Neilson

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Neurogenesis and brain injury: managing a renewable resource for repair
Anna F. Hallbergson, … , Carmen Gnatenco, Daniel A. Peterson
Anna F. Hallbergson, … , Carmen Gnatenco, Daniel A. Peterson
Published October 15, 2003
Citation Information: J Clin Invest. 2003;112(8):1128-1133. https://doi.org/10.1172/JCI20098.
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Neurogenesis and brain injury: managing a renewable resource for repair

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Abstract

The brain shows limited ability to repair itself, but neurogenesis in certain areas of the adult brain suggests that neural stem cells may be used for structural brain repair. It will be necessary to understand how neurogenesis in the adult brain is regulated to develop strategies that harness neural stem cells for therapeutic use.

Authors

Anna F. Hallbergson, Carmen Gnatenco, Daniel A. Peterson

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Sex is a potent modifier of the cardiovascular system
Leslie A. Leinwand
Leslie A. Leinwand
Published August 1, 2003
Citation Information: J Clin Invest. 2003;112(3):302-307. https://doi.org/10.1172/JCI19429.
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Sex is a potent modifier of the cardiovascular system

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Abstract

Authors

Leslie A. Leinwand

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C-reactive protein: a critical update
Mark B. Pepys, Gideon M. Hirschfield
Mark B. Pepys, Gideon M. Hirschfield
Published June 15, 2003
Citation Information: J Clin Invest. 2003;111(12):1805-1812. https://doi.org/10.1172/JCI18921.
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C-reactive protein: a critical update

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Abstract

Authors

Mark B. Pepys, Gideon M. Hirschfield

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SARS coronavirus: a new challenge for prevention and therapy
Kathryn V. Holmes
Kathryn V. Holmes
Published June 1, 2003
Citation Information: J Clin Invest. 2003;111(11):1605-1609. https://doi.org/10.1172/JCI18819.
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SARS coronavirus: a new challenge for prevention and therapy

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Abstract

Authors

Kathryn V. Holmes

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Comparative genomic tools and databases: providing insights into the human genome
Len A. Pennacchio, Edward M. Rubin
Len A. Pennacchio, Edward M. Rubin
Published April 15, 2003
Citation Information: J Clin Invest. 2003;111(8):1099-1106. https://doi.org/10.1172/JCI17842.
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Comparative genomic tools and databases: providing insights into the human genome

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Abstract

Authors

Len A. Pennacchio, Edward M. Rubin

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Lessons from viral manipulation of protein disposal pathways
Margo H. Furman, Hidde L. Ploegh
Margo H. Furman, Hidde L. Ploegh
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):875-879. https://doi.org/10.1172/JCI16831.
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Lessons from viral manipulation of protein disposal pathways

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Abstract

Spotlight

Authors

Margo H. Furman, Hidde L. Ploegh

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An increasingly complex code
Hugh T. Spotswood, Bryan M. Turner
Hugh T. Spotswood, Bryan M. Turner
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):577-582. https://doi.org/10.1172/JCI16547.
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An increasingly complex code

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Abstract

Spotlight

Authors

Hugh T. Spotswood, Bryan M. Turner

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