VEGF: a critical player in neurodegeneration
Erik Storkebaum, Peter Carmeliet
Erik Storkebaum, Peter Carmeliet
Published January 1, 2004
Citation Information: J Clin Invest. 2004;113(1):14-18. https://doi.org/10.1172/JCI20682.
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VEGF: a critical player in neurodegeneration

Abstract

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.

Authors

Erik Storkebaum, Peter Carmeliet

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