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ResearchIn-Press PreviewClinical ResearchOncology
Open Access | 
10.1172/JCI201090
EGFR- and HER3-targeted bispecific antibody-drug conjugate demonstrates anti-tumor activity in metastatic castration-resistant prostate cancer
Bangwei Fang,1 Xiaomeng Li,1 Ying Lu,2 Weiwei Ma,1 Hualei Gan,3 Tingwei Zhang,1 Qi Liu,2 Beihe Wang,1 Zixian Wang,2 Yi Zhu,4 Hai Zhu,4 Sa Xiao,5 Xiaojie Bian,1 Gonghong Wei,2 Dingwei Ye,1 and Yao Zhu1
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Fang, B. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Li, X. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Lu, Y. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Ma, W. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Gan, H. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Zhang, T. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Liu, Q. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Wang, B. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Wang, Z. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Zhu, Y. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Zhu, H. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Xiao, S. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Bian, X. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Wei, G. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Ye, D. in: PubMed | Google Scholar
1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Biochemistry and Molecular Biology of School of Basic Medical, Shanghai Medical College of Fudan University, Shanghai, China
3Department of Oncology, Fudan University, Shanghai, China
4Sichuan Biokin Pharmaceutical Co., Ltd., Chengdu, China
5Baili-Bio (Chengdu) Pharmaceutical Co., Ltd., Chengdu, China
Find articles by Zhu, Y. in: PubMed | Google Scholar
Published April 7, 2026 - More info
Copyright © 2026, Fang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)