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ResearchIn-Press PreviewCOVID-19Inflammation Free access | 10.1172/JCI149236
1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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You, J.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Wang, X.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Snider, A.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Hallmark, B.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Zec, M.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Johnstone, L.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
Find articles by Wang, Q. in: JCI | PubMed | Google Scholar
1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Carr, T.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Lutrick, K.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Luberto, C.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Hannun, Y.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Guerra, S.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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McCall, C.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Yao, G.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
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Del Poeta, M.
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1Department of Nutritional Sciences, University of Arizona, Tucson, United States of America
2Department of Microbiology and Immunology, Stony Brook University, Stony brook, United States of America
3Department of Molecular and Cellular Biology, University of Arizona, Tucson, United States of America
4BIO5 Institute, University of Arizona, Tucson, United States of America
5Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, United States of America
6Department of Biochemistry, Wake Forest School of Medicine, Tucson, United States of America
7Research Innovation and Impact - Core Facilities, University of Arizona, Tucson, United States of America
8Center for Applied Genetics and Genomic Medicine, University of Arizona, Tucson, United States of America
9Asthma and Airway Disease Research Center, University of Arizona, Tucson, United States of America
10Family and Community Medicine, College of Medicine, University of Arizona, Tucson, United States of America
11Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, United States of America
12Department of Mathematics, University of Arizona, Tucson, United States of America
13Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States of America
14Department of Pathology, Stony Brook University, Stony Brook, United States of America
15Department of Medicine, Stony Brook University, Stony Brook, United States of America
16Departments of Internal Medicine, Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, United States of America
17Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America
Find articles by Chilton, F. in: JCI | PubMed | Google Scholar
Published August 24, 2021 - More info
There is an urgent need to identify cellular/molecular mechanisms responsible for severe COVID-19 progressing to mortality. We initially performed untargeted/targeted lipidomics and focused biochemistry on 127 plasma samples and found elevated metabolites associated with secreted phospholipase A2 (sPLA2) activity and mitochondrial dysfunction in severe COVID-19 patients. Deceased COVID-19 patients had higher levels of circulating, catalytically active sPLA2 Group IIA (sPLA2-IIA), with a median value 9.6-fold higher than mild patients and 5.0-fold higher than severe COVID-19 survivors. Elevated sPLA2-IIA levels paralleled several indices of COVID-19 disease severity (e.g., kidney dysfunction, hypoxia, multiple organ dysfunction). A decision tree generated by machine learning identified sPLA2-IIA levels as a central node in stratifying patients that succumbed to COVID-19. Random forest analysis and LASSO-based regression analysis additionally identified sPLA2-IIA and blood urea nitrogen (BUN) as the key variables among 80 clinical indices in predicting COVID-19 mortality. The combined PLA-BUN index performed significantly better than either alone. An independent cohort (n=154) confirmed higher plasma sPLA2-IIA levels in deceased patients vs. severe or mild COVID-19, with the PLA-BUN index-based decision tree satisfactorily stratifying mild, severe, and deceased COVID-19 patients. With clinically tested inhibitors available, this study supports sPLA2-IIA as a therapeutic target to reduce COVID-19 mortality.