Objectives: Recent metabolomic studies of sepsis showed that increased circulatory
acylcarnitines were associated with worse survival. However, it is unknown whether plasma
carnitine and acylcarnitines can reflect the severity of sepsis, and the role of specific
acylcarnitines in prognostic assessment need further confirmation. This study aimed to
clarify these questions. Design: Prospective multicenter cohort studies with derivation and
validation cohort design. Setting: ICUs at two medical centers and three regional hospitals in …