Phospholipase A2 regulates critical inflammatory mediators of multiple organ failure
BO Anderson, EE Moore… - Journal of surgical …, 1994 - journalofsurgicalresearch.com
Multiple organ failure (MOF) clinically manifests as diffuse tissue injury and organ
dysfunction. Although provoked by an external insult or injury, MOF is propagated by
intrinsic inflammation [1, 2]. Increasing evi-dence suggests that endogenous inflammatory
cascades go awry in MOF and become biologically self-destructive [3]. As caretakers of the
critically ill, surgeons should familiarize themselves with these processes and their me-
diators to Optimize patient outcome. Although inflammation is a well—described physio …
dysfunction. Although provoked by an external insult or injury, MOF is propagated by
intrinsic inflammation [1, 2]. Increasing evi-dence suggests that endogenous inflammatory
cascades go awry in MOF and become biologically self-destructive [3]. As caretakers of the
critically ill, surgeons should familiarize themselves with these processes and their me-
diators to Optimize patient outcome. Although inflammation is a well—described physio …