Elevated plasma phospholipase A2 levels: correlation with the hemodynamic and pulmonary changes in gram-negative septic shock
P Vadas - The Journal of laboratory and clinical medicine, 1984 - translationalres.com
High levels of circulating phospholipase A 2 (PLA 2) have been implicated in the
pathogenesis of hypotension in experimental endotoxin shock. In an attempt to detect similar
mechanisms in clinical gram-negative septic shock, plasma samples from 34 patients with
hypotension and septicemia were collected and assayed for PLA 2 activity. PLA 2 levels in
100% of patients with septic shock were elevated (as high as 43-fold over control levels),
and mean plasma PLA 2 activity was increased 16-fold over control levels. Those patients …
pathogenesis of hypotension in experimental endotoxin shock. In an attempt to detect similar
mechanisms in clinical gram-negative septic shock, plasma samples from 34 patients with
hypotension and septicemia were collected and assayed for PLA 2 activity. PLA 2 levels in
100% of patients with septic shock were elevated (as high as 43-fold over control levels),
and mean plasma PLA 2 activity was increased 16-fold over control levels. Those patients …