The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid

G Atsumi, M Murakami, M Tajima, S Shimbara… - … et Biophysica Acta (BBA …, 1997 - Elsevier
Several lines of evidence have suggested that the plasma membranes of cells elicited by
proinflammatory stimuli or microvesicles shed from activated cells are sensitive to
extracellular type II secretory phospholipase A2 (sPLA2) that liberates fatty acids and
lysophospholipids. Here we report that the membranes of cells undergoing apoptosis are
highly susceptible to type II sPLA2. When neuronally differentiated rat pheochromocytoma
PC12 cells deprived of nerve growth factor and serum, mouse mast cells deprived of …