Circulating secretory phospholipase A2 in critical illness-the importance of the intestine

C Corke, K Glenister, T Watson - Critical Care and Resuscitation, 2001 - Elsevier
Objective: To review the role of secretory phospholipase A 2 in the pathogenesis of multiple
organ failure in the critically ill patient. Data sources: Relevant articles and published
reviews on secretory phospholipase A2 in critical illness. Summary of review: Secretory
phospholipase A 2 (sPLA 2) has an important role in inflammation and in antimicrobial
defence. However, excessive activity of sPLA 2 has been shown to result in tissue damage
and has been implicated as a mediator of organ failure associated with critical illness …