Crimean-Congo hemorrhagic fever virus glycoprotein 38 in mice is targeted with human antibodies

In this episode, James Crowe describes how these studies support the development of CCHFV countermeasures to induce protection against GP38 in vivo.

Wolfram syndrome and a phase II trial of sodium phenylbutyrate and taurursodiol

In this episode, Fumihiko Urano describes how the manuscript reports 24- and 48-week results from the ongoing HELIOS trial (ClinicalTrials.gov NCT05676034), a single-center, single-arm, open-label, phase II trial of PB&TURSO. Collectively, these results support continued development of PB&TURSO.

Distal wound healing is regulated by peritoneal macrophages via endocrine release

In this episode, Guido Beldi and Lilian Salm explain how their findings suggest that large peritoneal macrophages (LPMs), strategically positioned in the peritoneal cavity, serve as a source of circulating fibronectin, promoting matrix formation and accelerating wound healing at distant sites.

Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis

In this episode, Xiang-Yu Liu explains that the manuscript's findings revise the conventional view of GSH in protein redox and demonstrate that targeted redox manipulation through GSH depletion protects against MASLD.

CD8+ T cell neuroimmune surveillance following SIV infection is impaired by α4 integrin

In this episode Smita Iyer describe how the manuscript's findings establish that α4 integrin governs CD8-mediated neuroimmune surveillance through coordinated cellular positioning, with blockade enabling viral seeding while disrupting spatially organized antiviral defense.