Gina Aloisio and colleagues reveal that a PAX7-expressing population of spermatogonia serves as a stem-like population to sustain spermatogenesis...
Published August 18, 2014

In the August 2014 issue of the JCI, Chen et al. report that engineered bacteria can alter the gut microbiota and inhibit weight gain in a mouse model of obesity. The research team designed bacteria to produce a satiety factor known as N-acylphos
Published August 13, 2014

Ion channel activation inhibits intestinal tumorigenesis, Sex-dependent differences in glioblastoma, Identity of high-fat diet response-mediating neurons…
Published August 10, 2014

Jessica Sieren, David Meyerholz, and colleagues describe the development and application of a porcine model of cancer…
Published August 8, 2014

Age-related declines in immune function result in enhanced susceptibility to infection and decreased vaccine efficacy. While aged immune cells exhibit signs of cellular senescence, such as a reduced proliferative capacity, many maintain effector fun...
Published August 1, 2014