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Microglial activation and tau transmission aggravated by Galectin-3 in tauopathy
In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation...
Published January 16, 2024
Author's Take
Numerous shared tumor antigens in breast cancer immunopeptidomes
In this episode, Eralda Kina and Claude Perreault explain how using proteogenomics, their manuscript identifies tumor-specific antigens in primary human breast cancers...
Published January 2, 2024
Author's Take
Suppression by regulatory T cells and Foxp3-mediated blockage of ryanodine receptor 2
In this episode, Xiaobo Wang, Shuang Geng, and Junchen Meng explain how this work reestablished the suppressive functions in Tconvs absence of Foxp3 indistinguishable from Tregs by simply blocking RyR2 expression...
Published December 15, 2023
Author's Take
Predicting diabetic kidney disease and mediating kidney injury in patients with endogenous adenine
In this episode, Kumar Sharma explains that urine adenine/creatinine is a marker for kidney failure in patients with diabetes, and endogenous adenine plays a potential causative role in diabetic kidney disease...
Published November 2, 2023
Author's Take
JCI's Conversations with Giants in Medicine: Peter Hotez
A committed champion of vaccines and vaccine diplomacy, Dr. Peter Hotez is the Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology and Microbiology at the Baylor College of Medicine...
Published November 1, 2023
Conversations with Giants in Medicine
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