First Author Perspectives

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An interview with Matthew Hedberg
First author Matthew Hedberg discusses his research on HNSCC, its impact on disease management and treatment, and his training and career as an aspiring physician-scientist.
Published January 6, 2016
First Author Perspectives
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An interview with Pouneh Fazeli and Matthew Steinhauser
First and senior authors Pouneh Fazeli and Matthew Steinhauser discuss their research indicating the differential role of FGF21 in response to fasting in mice and humans, as well as their life as a married couple pursuing careers as physician-scientists.
Published November 10, 2015
First Author Perspectives
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An interview with Alice Wang
Alice Wang's group provides new molecular insights into the effects of maternal smoking on impairing fetal growth; she shares her experiences from this project and how she incorporates research with clinical work as a neonatologist.
Published September 29, 2015
First Author Perspectives
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An interview with Rohit Sharma
Rohit Sharma discusses a novel mechanism by which pancreatic β cells proliferate, the ways in which his past work informed his current understanding of the UPR pathway, and his advice for young trainees just beginning their research careers.
Published September 21, 2015
First Author Perspectives
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An interview with Xudong Liao
Xudong Liao about his work on the role of KLF4 in mitochondrial regulation, his personal reflections on training in two different countries, and his advice on how to succeed in biomedical research.
Published August 4, 2015
First Author Perspectives
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An interview with Gunnar Houge
Gunnar Houge discusses his research indicating that protein phosphatase 2A dysfunction is causative of pathogenesis in a subset of ID patients.
Published July 13, 2015
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An Interview with Sallie Permar
Sallie Permar discusses her work on humoral immune responses in mother-to-child transmission of HIV-1, as well as her career path.
Published June 8, 2015
First Author Perspectives
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An Interview with Daniel Abravanel
First author Daniel Abravanel discusses work exploring the role of Notch signaling in breast cancer recurrence and dormancy.
Published May 13, 2015
First Author Perspectives
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An interview with Kristen Pollizzi
First author Kristen Pollizzi discusses research providing insight into how the mTOR pathway regulates CD8+ T cell effector function and memory commitment.
Published April 20, 2015
First Author Perspectives
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An interview with Keith Choate
First author Keith Choate discusses recently published research implicating KRT1 in the high frequency of revertant mosaicism in ichthyosis with confetti.
Published March 16, 2015
First Author Perspectives
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An interview with Yulong Chen and Masahiko Terajima
Yulong Chen and Masahiko Terajima discuss their research published in the March 2015 issue of the JCI identifying a crosstalk mechanism by which lung tumor cells become more metastatic via alteration of the chemical nature of the collagen crossli
Published February 9, 2015
First Author Perspectives
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An interview with Markus Huth
Markus Huth discusses research demonstrating that modification of a class of antibiotics known as aminoglycosides reduces detrimental side effects affecting hearing by blocking entry of the drugs into sensory hair cells cells via mechanotransduction chan
Published January 6, 2015
First Author Perspectives
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An interview with Rupert Kenefeck
Rupert Kenefeck discusses research published in the January 2015 issue that provides a novel framework for therapeutic intervention and biomarker identification in the setting of type 1 diabetes.
Published December 11, 2014
First Author Perspectives
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An interview with Jaerak Chang and Seongju Lee
In the December issue of the JCI, Jaerak Chang and Seongju Lee discuss their research into the mechanisms underlying two commonly mutated genes in hereditary spastic paraplegia
Published November 3, 2014
First Author Perspectives
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An interview with Barbara Wegiel
In the November issue of the JCI, Wegiel et al. describe a unique mechanism whereby carbon monoxide (CO) produced by heme oxygenase 1 (HO-1) in macrophages results in ATP production by several bacteria.
Published October 8, 2014
First Author Perspectives
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An interview with Alexander Gill
A research article in the October 2014 issue of the JCI describes the role of heme oxygenase–1 (HO-1) in the neuropathophysiology of HIV and suggests that HO-1 serves as a protective factor against neurodegeneration in HIV-associated neurocognitive disord
Published September 9, 2014
First Author Perspectives
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An interview with Gaetano Santulli
A research article in the September 2014 issue of the JCI identifies a microRNA-based strategy that inhibits arterial restenosis while preserving endothelial function. The authors created an adenoviral vector encoding the cyclin-dependent kinase inhibitor
Published August 18, 2014
First Author Perspectives
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An interview with Lilu Guo and Zhongyi Chen
In the August 2014 issue of the JCI, Chen et al. report that engineered bacteria can alter the gut microbiota and inhibit weight gain in a mouse model of obesity. The research team designed bacteria to produce a satiety factor known as N-acylphos
Published August 13, 2014
First Author Perspectives
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An interview with Jamie Anastas
A research article in the July 2014 issue of JCI identifies resistance mechanisms of BRAF-mutant melanoma cells to targeted therapy among the WNT signaling pathways, specifically WNT5A. This research uncovers a means of acquired resistance to tar
Published July 11, 2014
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