Author's Takes

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Cerebrospinal fluid quinolinic acid and delirium and mortality in hip-fracture patients
In this episode, Lasse Giil explains that activation of the kynurenine pathway in delirium leads to high brain concentrations the endogenous neurotoxin quinolinic acid...
Published January 20, 2023
Author's Take
BMX controls in cancer
In this episode, Nima Sharifi and Xiuxiu Li discuss how the BMX kinase regulates androgen and estrogen biosynthesis and is a drug target for sex steroid dependent cancers...
Published January 17, 2023
Author's Take
CD69 expression protects from immune damage after MI
In this episode, Dr. Blanco-Domínguez discusses CD69 expression on regulatory T cells after myocardial infarction controls immune homeostasis...
Published November 1, 2022
Author's Take
Durability of AZD1222 COVID-19 vaccine over 6 months
In this episode, Magdalena Sobieszczyk explains the paper and that it provides comprehensive safety information and data on durability of protection and immunogenicity of AZD1222...
Published September 15, 2022
Author's Take
Immune responses and the rejection of colonized solid organ transplants
In this episode, Isabella Pirozzolo explains that following transplantation, microbiota-colonized organs have a shorter half-life than sterile organs. In the paper, the authors show that host-versus-commensal immunity participates in graft damage...
Published September 1, 2022
Author's Take
Targeting hepatic kisspeptin receptors and nonalcoholic fatty liver disease
In this episode, Stephania Guzman explains that this study establishes the kisspeptin receptor as a therapeutic target to treat nonalcoholic fatty liver disease...
Published May 18, 2022
Author's Take
Food addiction vulnerability in mice and humans and miRNA signatures
In this episode, Rafael Maldonado and Elena Martín-García explain how similar patterns of miRNAs signatures of food addiction vulnerability are present in animals and humans...
Published May 16, 2022
Author's Take
Efferocytosis induces VEGFC to improve cardiac injury and inflammation
In this episode, Guillermo Oliver and Ed Thorp discuss how cardiac VEGF-C is sourced from macrophages after efferocytosis to ameliorate cardiac injury and inflammation...
Published May 2, 2022
Author's Take
Gut-derived bacterial toxins and HIV-1 infection
In this episode, Souheil-Antoine Younes explains that their findings propose that toxic solutes from the gut bacterial flora may impair CD4+ T cell recovery during ART and may contribute to CD4+ T cell lymphopenia characteristic of INRs...
Published May 2, 2022
Author's Take
Tertiary lymphoid tissue expansion and kidney injury are promoted by CD153/CD30 signaling
In this episode, Motoko Yanagita and Yuki Sato explain that CD153-CD30 signaling is required for tertiary lymphoid tissue expansion and represents a therapeutic target for kidney diseases in the elderly...
Published January 31, 2022
Author's Take
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