Author's Take

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Secondary insult reveals etiology of GATA2 enhancer mutation-associated blood disorder
In this episode, Emery Bresnick and colleagues reveal that a blood disorder-associated GATA2 mutation does not affect developmental hematopoiesis but results in defective regeneration in response to stress…
Published March 1, 2019
Author's Take
Naturally occurring cone disorder in nonhuman primates
In this episode, Sara Thomasy, Ala Moshiri, and colleagues identify and characterize an inherited retinal disease in nonhuman primates that recapitulates human achromatopsia…
Published February 14, 2019
Author's Take
Sphingolipid desaturase DEGS1 linked to rare leukodystrophy
In this episode, Aurora Pujol and colleagues identify loss of endoplasmic reticulum lipid desaturase DEGS1 as the underlying driver of disease in patients with a rare leukodystrophy…
Published February 11, 2019
Author's Take
Mast cell engagement of γδ T cells protects against viral infection
In this episode, Ashley St. John and colleagues reveal that mast cell engagement of γδ T cells in the skin limits dengue infection…
Published February 4, 2019
Author's Take
Strain aneuploidy underlies fluconazole resistance in human cryptococcal meningitis
In this episode, Neil Stone and colleagues identify aneuploidy as a driver of fluconazole resistance in human cryptococcal meningitis…
Published January 28, 2019
Author's Take
Screen identifies group A streptococcus genes important for necrotizing disease
In this episode, James Musser and colleagues identify group A streptococcus genes that contribute to the development of necrotizing myositis…
Published January 22, 2019
Author's Take
Murine model of autism-like syndrome benefits from NAP treatment
In this episode, Illana Gozes and colleagues reveal that NAP improves development and behavioral defects in murine model of an autism-like syndrome…
Published September 24, 2018
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REG3α as a biomarker and therapeutic target for GVHD
In this episode, James Ferrara and colleagues identify the REG3α as a GI GVHD-specific biomarker…
Published September 24, 2018
Author's Take
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
In this episode, Neil Bhowmick and colleagues reveal that epigenetic changes in prostate cancer-associated fibroblasts promote tumor growth and development of resistance to androgen depravation….
Published September 4, 2018
Author's Take
Vitamin D3 metabolite enables bone fracture repair
In this episode, René St-Arnaud and colleagues identify a 24R,25-dihydroxyvitamin D3–dependent pathway involved in bone repair...
Published July 16, 2018
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