Author's Take

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Mature myelin maintenance requires Qki to coactivate metabolism
In this episode, Jian Hu and colleagues demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases...
Published April 4, 2020
Author's Take
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation
In this episode, Vijay Singh and colleagues reveal that Pancreatic lipase-mediated necrosis of visceral fat worsens outcomes in acute pancreatitis…
Published March 9, 2020
Author's Take
Interferon signature in undifferentiated systemic autoinflammatory diseases
In this episode, Raphaela Goldbach-Mansky, Adriana de Jesus, and colleagues use a comprehensive approach to identify autoinflammatory diseases that present with elevated interferon signature…
Published February 24, 2020
Author's Take
IL-36γ induction underlies EGFR inhibitor-associated skin toxicity
In this episode, Lars French, Takashi K. Satoh and colleagues show that EGFR/MEK inhibitors and the commensal Cutibacterium acnes synergistically induce IL-36γ in keratinocytes, resulting in neutrophilic acneiform skin toxicities…
Published February 4, 2020
Author's Take
CD8+ T cell function may predict type 1 diabetes progression
In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive CD8+ T cells…
Published December 9, 2019
Author's Take
Fibronectin variant mediates smooth muscle cell phenotypic switching
In this episode, Anil Chauhan, Manish Jain, and colleagues reveal that smooth muscle cell- specific fibronectin containing an extra domain A mediates phenotypic switching and neointimal hyperplasia…
Published November 25, 2019
Author's Take
Characterization of FOXN1 mutation-mediated immune deficiency
In this episode, Nicolai van Oers and colleagues demonstrate that compound heterozygous mutations in FOXN1 result in a combined immunodeficiency in patients that is distinct Nude/SCID phenotypes…
Published October 1, 2019
Author's Take
Breast milk-derived alkylglycerols support beige adipose tissue
In this episode, Tamás Röszer and colleagues demonstrate that breast-milk-derived alkylglycerols preserve beige adipocytes to protect against obesity…
Published May 13, 2019
Author's Take
Secondary insult reveals etiology of GATA2 enhancer mutation-associated blood disorder
In this episode, Emery Bresnick and colleagues reveal that a blood disorder-associated GATA2 mutation does not affect developmental hematopoiesis but results in defective regeneration in response to stress…
Published March 1, 2019
Author's Take
Naturally occurring cone disorder in nonhuman primates
In this episode, Sara Thomasy, Ala Moshiri, and colleagues identify and characterize an inherited retinal disease in nonhuman primates that recapitulates human achromatopsia…
Published February 14, 2019
Author's Take
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