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Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells.
In this episode, Aaron R. Mangold explains how lichen planus is treated by suppressing cytotoxic CXCL13+CD8+ T-cells using baricitinib...
Published March 31, 2025
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Electronic health record data and the estimation of autoimmune disease prevalence in the USA
In this video, DeLisa Fairweather, Aaron H. Abend, and Ingrid He explain that their paper estimates the prevalence of all autoimmune disease in the US...
Published February 17, 2025
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Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib
In this episode, Laura Ondrisova describes how this manuscript examines a non-genetic adaptation to BTK inhibitor therapy in chronic lymphocytic leukemia that involves Akt activation via FoxO1/Rictor axis...
Published December 2, 2024
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Macrophage subtypes mediate the development of the ordered architecture of regenerative tissues
In this episode, Andreas Patsalos and Laszlo Nagy explain that their findings suggest that macrophage subtypes mediated the development of the highly ordered architecture of regenerative tissues...
Published November 22, 2024
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A dynamic multilayered tissue architecture is revealed in skeletal muscle
In this episode, Laszlo Nagy and colleagues, explain that macrophages coordinate tissue repair by promoting regenerative inflammation...
Published October 15, 2024
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ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts
In this episode, Rafael Kramann, Konrad Hoeft, and Lars Koch explain that catalytically active ADAMTS12 controls fibrosis by restructuring ECM to enable activation and migration of a distinct injury-responsive fibroblast subset after injury...
Published September 17, 2024
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Sex- and age-specific differences revealed by mouse sarcopenia models
In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function...
Published August 15, 2024
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Tet2 function and innate immune resistance to bacterial pneumonia
In this episode, Candice Quin explains how individuals with TET2-mutant CHIP are at increased risk of bacterial pneumonia due to innate immune impairments...
Published July 17, 2024
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Prolonged transplant survival in preclinical models
In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival...
Published April 24, 2024
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A glycolysis/HIF1a axis in promoting G-MDSC activity and biofilm persistence during PJI is important
In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI...
Published April 23, 2024
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