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Crimean-Congo hemorrhagic fever virus glycoprotein 38 in mice is targeted with human antibodies
In this episode, James Crowe describes how these studies support the development of CCHFV countermeasures to induce protection against GP38 in vivo...
Published May 15, 2026
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Wolfram syndrome and a phase II trial of sodium phenylbutyrate and taurursodiol
In this episode, Fumihiko Urano describes how the manuscript reports 24- and 48-week results from the ongoing HELIOS trial (ClinicalTrials.gov NCT05676034), a single-center, single-arm, open-label, phase II trial of PB&TURSO...
Published May 15, 2026
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Distal wound healing is regulated by peritoneal macrophages via endocrine release
In this episode, Guido Beldi and Lilian Salm explain how their findings suggest that large peritoneal macrophages (LPMs), strategically positioned in the peritoneal cavity, serve as a source of circulating fibronectin...
Published May 1, 2026
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Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis
In this episode, Xiang-Yu Liu explains that the manuscript's findings revise the conventional view of GSH in protein redox and demonstrate that targeted redox manipulation through GSH depletion protects against MASLD...
Published April 15, 2026
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CD8+ T cell neuroimmune surveillance following SIV infection is impaired by α4 integrin
In this episode Smita Iyer describe how the manuscript's findings establish that α4 integrin governs CD8-mediated neuroimmune surveillance through coordinated cellular positioning...
Published April 15, 2026
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A tuberculosis cure is accelerated by immunotherapy targeting
In this episode, Styliani Karanika describes how their findings underscore the potential of a strategy to advance therapeutic TB vaccine development targeting M. tuberculosis persisters...
Published April 10, 2026
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Genome/exome sequencing underestimates CHIP–disease associations
In this episode, Dr. Alexander G. Bick discusses how epidemiology studies underestimate how strongly clonal hematopoiesis is linked to disease because shallow whole-genome sequencing produces more false negatives compared with deep targeted sequencing...
Published April 8, 2026
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Predicting chronic graft-versus-host disease and mortality risk with BIOPREVENT
In this episode, Sophie Paczesny explains that BIOPREVENT accurately predicts individual risk of future cGVHD and NRM using biomarkers at 3 months post-HCT...
Published February 26, 2026
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Protective, subtype antibody family targets the active site of influenza A virus neuraminidase
In this episode, Dr. Seth J. Zost presents an antibody lineage from a single donor that binds the active site of influenza neuraminidase, cross-reacts with antigenically diverse viruses, and protects mice from infection...
Published December 1, 2025
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Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation
In this episode, Marie Jeansson explains how the paper's findings suggest that TIE2 activation via angiopoietin-2 (ANGPT2)-binding and TIE2-activating antibody warrants investigation as a therapy in human CKD...
Published November 3, 2025
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