Author's Take

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Variant increases ER chaperones GRP78 and GRP94 and protects against liver injury
In this episode, Richard Austin, Paul Lebeau, and Michel Chrétien explain that the human Q152H ProPCSK9 mutation acquires an unexpected novel function: protection against ER stress and liver injury by enhancing chaperone expression...
Published January 19, 2021
Author's Take
Increased atrial fibrillation in diabetic mice by distinct mechanisms
In this episode, Olurotimi O. Mesubi explains that the discovery of oxidation of CaMKII and O-GlcNAcylation differentially increased atrial fibrillation risk in type 1 and type 2 diabetic mice...
Published January 19, 2021
Author's Take
mTOR-dependent translation amplifies microglia priming
In this episode, Melania Capasso explains how mTOR is hyperactivated in microglia with age and causes increased translation of inflammatory mediators, thus critically regulating microglia priming...
Published January 4, 2021
Author's Take
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
Persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes...
Published November 16, 2020
Author's Take
Germ cell tumors and other malignancies evolve from a shared precursor
In this episode, Justin Taylor and colleagues identify the genomic characteristics and clonal origins of a unique and aggressive clinical syndrome involving clonally related hematologic malignancies and germ cell tumors...
Published November 16, 2020
Author's Take
Kisspeptin receptor agonist and female reproductive disorders
In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native kisspeptin-54, and thus increased therapeutic potential to treat female reproductive...
Published November 16, 2020
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Maintenance DNA methylation is essential for development and stability
In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell identity and suppressive function during both development and lineage self-renewal...
Published November 9, 2020
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Vaccine targeting protects macaques against vaginal infection
In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates of vaccine efficacy...
Published November 3, 2020
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Anti-influenza antibody in hemagglutinin head domain interface
In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers...
Published August 4, 2020
Author's Take
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity...
Published July 27, 2020
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