Author's Take

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REV-ERBα controls the clock in the lung
In this episode, David Ray, Marie Pariollaud and colleagues identify REV-ERBα as a critical regulator of rhythmic inflammatory responses in the lung…
Published April 30, 2018
Author's Take
Immune tolerance-like pathway inhibits repair following white matter injury
Stephen Back and colleagues identify an immune tolerance-like pathway that prevents repair after white matter injury…
Published April 16, 2018
Author's Take
Vaginal epithelial shedding mediates ascending group B streptococcus infection
In this episode, Lakshmi Rajagopal provide evidence that group B streptococcus-induced exfoliation of the vaginal epithelium promotes ascending infection…
Published April 9, 2018
Author's Take
A role for plasminogen activator inhibitor type 1 in skin fibrosis
In this episode, Colin Jamora, Neha Pincha, and colleagues demonstrate a role for plasminogen activator inhibitor type 1 in driving fibrogenesis in a murine model of skin fibrosis…
Published March 26, 2018
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CD163+ macrophages serve pathogenic role in atherosclerosis
In this episode Aloke Finn, Liang Guo and colleagues reveal that a population of alternatively activated CD163+ macrophages, previously thought to be atheroprotective, are instead pathogenic….
Published February 19, 2018
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Tie1 deficiency limits cancer progression and metastasis
In this episode, Hellmut Augustin, Silvia La Porta, and colleagues link the orphan receptor Tie1 within intratumoral vasculature to cancer progression and metastasis…
Published January 22, 2018
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Identification and characterization of GDF6 as a driver of melanoma
In this episode, Craig Ceol, Arvind Venkatesan, and colleagues identify GDF6-mediated BMP signaling as a driver of melanoma and potential therapeutic target...
Published December 4, 2017
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Increased cardiomyocyte proliferation benefit depends on the heart injury
Gerd Hasenfuß, Loren Field, and Karl Toischer demonstrate that enhancing cardiomyocyte regeneration is beneficial for some, but not all, forms of heart failure…
Published October 30, 2017
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Human breast milk-derived commensal limits pathogenic inflammation
Mansour Mohamadzadeh and colleagues identify a commensal Propionibacterium in human breast milk that ameliorates intestinal inflammation...
Published September 25, 2017
Author's Take
Angiopoietin/Tie2 maintain the flow of Schlemm’s canal
Gou Young Koh, Jaeryung Kim, and Dae-Young Park discuss their work, which identifies angiopoietin/Tie2 as a critical pathway in maintaining the integrity and function of Schlemm’s canal…
Published September 18, 2017
Author's Take
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