Author's Take

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Zonulin-dependent loss of gut mucosal barrier and MIS-C
In this episode, the authors explain that in multisystem inflammatory syndrome in children (MIS-C), increased gastrointestinal mucosal permeability allows SARS-CoV-2 antigens in the GI tract to leak into the bloodstream...
Published July 15, 2021
Author's Take
Hemophilia A and immune response
In this episode, Valder Arruda explains that depletion of the cytokine B cell activating factor in hemophilia A may provide a way to prevent or eradicate factor VIII inhibitors...
Published July 9, 2021
Author's Take
Efficient maternal to neonatal transfer of antibodies
In this episode, Michal Kovo explains that antenatal BNT162b2 mRNA vaccination induces a robust maternal humoral response that effectively transfers to the fetus, supporting the role of vaccination during pregnancy...
Published July 1, 2021
Author's Take
Immune checkpoint receptors for HBV infection
In this episode, Shie-Liang Hsieh and Tsung-Yu Tsai explain that HBV interacts with SIGLEC-3 and causes impairment of host immunity...
Published June 1, 2021
Author's Take
CCL17-producing cDC2s in end-stage lupus nephritis and parasitic infections
In this episode, Laura Amo and Silvia Bolland explain that the infiltration into kidneys of iDC2s, with potential to prime local adaptive responses, is an essential regulated event...
Published June 1, 2021
Author's Take
Frataxin deficiency and pulmonary hypertension
In this episode, Stephen Chan explains that genetic and acquired frataxin deficiency disrupts genomic integrity to induce endothelial senescence and represents a common mechanism for multiple pulmonary hypertension subtypes...
Published June 1, 2021
Author's Take
Regulation of proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy
In this episode, Farah Sheikh presents the identification of a desmosomal COP9 signalosome regulatory complex that restricts desmosomal proteome degradation and genetic cardiac desmosomal disease, arrhythmogenic right ventricular cardiomyopathy...
Published June 1, 2021
Author's Take
Thymosin β4 protects against aortic aneurysm
In this episode, Nicola Smart, Sonali Munshaw, and Susann Bruche present their findings that Thymosin β4 is a regulator of LRP1, which protects against aortic aneurysm by regulating PDGFRβ endocytosis and smooth muscle phenotype...
Published May 17, 2021
Author's Take
Impairing melanoma phenotype switching and potentiating antitumor immune responses
In this episode, Sonia del Rincón and Fan Huang explain that inhibiting the MNK1/2-eIF4E axis dampens melanoma plasticity and enhances response to anti-PD-1 immunotherapy...
Published April 22, 2021
Author's Take
Lipid-induced cell adhesion promotes nonalcoholic steatohepatitis pathogenesis
In this episode, Samar Ibrahim explains that lipotoxic stress enhances the expression of LSEC-VCAM-1, in part, through MLK3 signaling...
Published March 15, 2021
Author's Take
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