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Anti-influenza antibody in hemagglutinin head domain interface
In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and disrupts HA trimers...
Published August 4, 2020
Author's Take
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by pro-inflammatory cytokines to amplify Th17 cell pathogenicity and autoimmunity...
Published July 27, 2020
Author's Take
T cells prevent and treat graft-versus-host disease
In this episode, Marco Davila and Brian Betts explain that taking advantage of the differential expression of CD83, human CD83-targeted CAR T cells prevent and treat GVHD, as well as kill myeloid leukemia...
Published July 27, 2020
Author's Take
Microenvironmental Th9 and Th17 induce spreading in lung cancer
In this episode, Rajkumar Savai and colleagues explain that Th9 and Th17 lymphocytes induce lung cancer cell epithelial-mesenchymal transition via release of their signature cytokines, thereby promoting migration, vessel entry, and metastatic spreading...
Published June 2, 2020
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S100A8/A9 regulates during chronic tuberculosis
In this episode, Shabaana Khader and Rosemary Swanson discuss how the alarmin S100A8/A9 mediates neutrophil accumulation during progression to chronic TB...
Published May 11, 2020
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Erythrocyte-derived microvesicles induce arterial spasms
In this Episode, Johanne Poisson, Marion Tanguy, Pierre-Emmanuel Rautou, and colleagues discuss that the high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPN suggests that vascular function
Published April 20, 2020
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MICAL1 constrains and protects against disease by oxidizing CaMKII
In this episode, Mark Anderson explains that the stereospecific redox status of CaMKII Methionine 308 regulates CaMKII activation and determines physiological and pathological cardiac responses to stress across species...
Published April 4, 2020
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Mature myelin maintenance requires Qki to coactivate metabolism
In this episode, Jian Hu and colleagues demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases...
Published April 4, 2020
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Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation
In this episode, Vijay Singh and colleagues reveal that Pancreatic lipase-mediated necrosis of visceral fat worsens outcomes in acute pancreatitis…
Published March 9, 2020
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Interferon signature in undifferentiated systemic autoinflammatory diseases
In this episode, Raphaela Goldbach-Mansky, Adriana de Jesus, and colleagues use a comprehensive approach to identify autoinflammatory diseases that present with elevated interferon signature…
Published February 24, 2020
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