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ResearchIn-Press PreviewAutoimmunityDermatology
Open Access |
10.1172/JCI197665
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Fang, H. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Li, K. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Wang, B. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Miao, H. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Bai, Y.
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Li, L. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Li, X. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Qiao, P. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Find articles by Qiao, H. in: PubMed | Google Scholar
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Shao, S.
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Dang, E.
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1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
3Department of Dermatology, Tangdu Hospital, Fourth MIlitary Medical University, Xi'an, China
4Department of Dermatology,, Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Wang, G.
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Published July 7, 2026 - More info
CD20+ T cells are increasingly recognized as drivers of autoimmune and inflammatory diseases. However, their origin, development, and specific role in autoimmune skin diseases remain poorly understood. In this study, we observed an expansion of CD20+ T cells in the peripheral blood and skin lesions of patients with bullous pemphigoid (BP), which correlated with the levels of pathogenic autoantibodies and disease severity. Compared with CD20– T cells, CD20+ T cells exhibited enhanced metabolic and proinflammatory activities. In particular, antigen-specific BP180-NC16A-reactive T cells were enriched within the CD4+CD20+ subset. In both patients with BP and BP180-immunized mice, CD4+CD20+ T cells exhibited an antigen-specific follicular helper T (Tfh)-like phenotype, facilitating antibody production and B cell differentiation, whereas CD8+CD20+ T cells displayed cytotoxic and proinflammatory features. Mechanistically, we found that expression of the CD20-encoding gene MS4A1 in T cells was regulated by PAX5 in a DNA methylation-dependent manner. Therefore, our study elucidates the regulatory mechanisms governing CD20+ T cells and highlights their important role in the pathogenesis of BP.