T cell receptor signaling induces expression of lysine demethylase KDM6B to maintainTreg homeostasis

¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States of America

²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States of America

³Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁴Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁵Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁶Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁷Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁸Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, United States of America

⁹Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States of America

¹⁰Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, United States of America

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