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ResearchIn-Press PreviewHematologyInflammation
Open Access | 
10.1172/JCI184285
Mutant p53 promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment
Sisi Chen,1 Sergio Barajas,2 Sasidhar Vemula,3 Yuxia Yang,3 Ed Simpson,4 Hongyu Gao,4 Rudong Li,4 Farzaneh Behzadnia,4 Sarah C. Nabinger,3 David A. Schmitz,3 Hongxia Chen,2 Wenjie Cai,2 Shiyu Xiao,2 Ruyue Luo,2 Mohammed Abdullahel Amin,2 Maegan L. Capitano,5 James P. Ropa,5 Aidan Fahey,3 Shuyi Zhou,1 Tiffany M. Mays,2 Magdalena Sotelo,2 Hao Pan,2 Sophie K. Hu,2 Sophia Veranga,2 Moiez Ali,2 Maria Shumilina,2 Reuben Kapur,3 Kehan Ren,6 Yuzhi Jia,7 Huiping Liu,7 Irum Khan,2 Yasmin Abaza,2 Jessica K. Altman,2 Elizabeth A. Eklund,2 Lucy A. Godley,2 Christine R. Zhang,6 Peng Ji,6 Seth L. Masters,8 Ben A. Croker,9 H. Scott Boswell,10 George E. Sandusky,11 Zhonghua Gao,12 Lindsey D. Mayo,3 Sharon A. Savage,13 Stephanie Halene,14 Yali Dou,15 Leonidas C. Platanias,2 Madina Sukhanova,6 Yunlong Liu,4 Omar Abdel-Wahab,16 and Yan Liu2
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Vemula, S. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Simpson, E. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Gao, H. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Li, R. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Behzadnia, F. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Nabinger, S. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Schmitz, D. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Chen, H. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Cai, W. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Xiao, S.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Find articles by Luo, R. in: PubMed | Google Scholar
1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Ropa, J.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Ren, K.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Liu, H.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Godley, L.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Ji, P.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Croker, B.
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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1Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America
6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
7Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
8The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
9Department of Pediatrics, University of California San Diego, La Jolla, United States of America
10Department of Medicine, Indiana University School of Medicine, Indianapolis, United States of America
11Department of Pathology and Laboratory Medicine, Indiana University School of Medicine,, Indianapolis, United States of America
12Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, United States of America
13Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, United States of America
14Department of Internal Medicine and Yale Cancer Cente, Yale University School of Medicine, New Haven, United States of America
15Department of Medicine, University of Southern California, Los Angeles, United States of America
16Molecular Pharmacology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, United States of America
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Published December 30, 2025 - More info
Copyright © 2025, Chen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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