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ResearchIn-Press PreviewOncology
Open Access | 10.1172/JCI184043
1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
Find articles by Sawyer, W. in: PubMed | Google Scholar
1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, United States of America
2The Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, United States of America
3Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, United States of America
4Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, United States of America
5Division of Quantitative Sciences, Department of Biostatistics, University of Florida Health Cancer Center, University of Florida, Gainesville, China
6Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, China
7Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, United States of America
8Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, United States of America
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Published July 1, 2025 - More info
Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME) and dampen the immune response, negatively affecting patient survival. Therefore, targeting TAMs could address the limitations of current cancer treatments. However, drug development in this area remains limited. The Leukocyte-associated Immunoglobulin-like Receptor-1 (LAIR1), also called CD305, is prominently expressed on the surface of TAMs. We have uncovered a previously unrecognized immunosuppressive LAIR1 → Factor XIII A (FXIII-A) → Collagen IV pathway across various cancer types. Inhibition of LAIR1, either through knockout (Lair1–/–), antibody blockade (aLAIR1), or a chimeric antigen receptor (CAR) design (3-in-1 CAR by combining tumor targeting, T cell trafficking, and remodeling of the immunosuppressive TME in one CAR construct) provides enhanced antitumor response. LAIR1 inhibition enhances peripheral and intratumoral CD8 memory T-cell populations, induces a phenotypic shift of M2-like Macrophages towards M1, and normalizes tumor collagen IV and structural components in the TME, facilitating effective tumor-T cell interactions and tumor suppression. Enhanced antitumor responses were observed when Lair1–/– or aLAIR1 was used alone or combined with CAR T cells or when the 3-in-1 CAR T cells were used solely in chemotherapy-radiation-PD-1 blockade-resistant tumor models. These findings position LAIR1 inhibition as a promising strategy for cancer immunotherapies.