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ResearchIn-Press PreviewNephrology
Open Access | 10.1172/JCI170341
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Sharma, K.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Zhang, G.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Hansen, J.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Bjornstad, P. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Lee, H.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Menon, R.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Hejazi, L. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Liu, J. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Franzone, A. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Looker, H.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Choi, B.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Fernandez, R. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Kugathasan, L.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Sridhar, V.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Natarajan, L. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Kwan, B.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Waikar, S.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Himmelfarb, J.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Tuttle, K.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Fuhrer, T.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Feldman, H.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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de Boer, I.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Tucci, F.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Sedor, J.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Heerspink, H.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Otto, E.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Hodgin, J.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Kretzler, M.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
Find articles by Anderton, C. in: JCI | PubMed | Google Scholar
1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Alexandrov, T.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Lim, S.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Nelson, R.
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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1Medicine, The University of Texas Health San Antonio, San Antonio, United States of America
2Pharmacological Sciences, Icahn School of Medicine, New York, United States of America
3Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America
4Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
5Clinical Research Unit, Khoo Teck Puat Hospital, Yishun, Singapore
6Chronic Kidney Disease Section, NIDDK, Phoenix, United States of America
7Department of Population Health Sciences, The University of Texas Health San Antonio, San Antonio, United States of America
8Department of Pathology, The University of Texas Health San Antonio, San Antonio, United States of America
9Department of Medicine, Division of Nephrology, Toronto General Research Institute - University Health Network, Toronto, Canada
10Department of Family Medicine and Public Health, UC San Diego, La Jolla, United States of America
11Bock Lab, Center for Molecular Medicine, Vienna, Austria
12Department of Biostatistics, UCLA, Los Angeles, United States of America
13Section of Nephrology, Boston University School of Medicine, Boston, United States of America
14Kidney Research Institute, Department of Medicine, University of Washington, Seattle, United States of America
15Nephrology, University of Washington, Seattle, United States of America
16Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
17University of Pennsylvania, Philadelphia, United States of America
18Epigen Biosciences, Inc., San Diego, United States of America
19Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
20Clinical Pharmacology, Faculty of Medical Sciences - University of Groningen, Groningen, Netherlands
21University of Michigan, Ann Arbor, United States of America
22Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States of America
23Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Published August 24, 2023 - More info
Diabetic kidney disease (DKD) can lead to end-stage kidney disease (ESKD) and mortality, however, few mechanistic biomarkers are available for high risk patients, especially those without macroalbuminuria. Urine from participants with diabetes from Chronic Renal Insufficiency Cohort (CRIC), Singapore Study of Macro-Angiopathy and Reactivity in Type 2 Diabetes (SMART2D), and the Pima Indian Study determined if urine adenine/creatinine ratio (UAdCR) could be a mechanistic biomarker for ESKD. ESKD and mortality were associated with the highest UAdCR tertile in CRIC (HR 1.57, 1.18, 2.10) and SMART2D (HR 1.77, 1.00, 3.12). ESKD was associated with the highest UAdCR tertile in patients without macroalbuminuria in CRIC (HR 2.36, 1.26, 4.39), SMART2D (HR 2.39, 1.08, 5.29), and Pima Indian study (HR 4.57, CI 1.37-13.34). Empagliflozin lowered UAdCR in non-macroalbuminuric participants. Spatial metabolomics localized adenine to kidney pathology and transcriptomics identified ribonucleoprotein biogenesis as a top pathway in proximal tubules of patients without macroalbuminuria, implicating mammalian target of rapamycin (mTOR). Adenine stimulated matrix in tubular cells via mTOR and stimulated mTOR in mouse kidneys. A specific inhibitor of adenine production was found to reduce kidney hypertrophy and kidney injury in diabetic mice. We propose that endogenous adenine may be a causative factor in DKD.