Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI105923

The determination of total body exchangeable O2 stores

Carroll E. Cross, Bernard S. Packer, Michael Altman, J. Bernard L. Gee, H. Victor Murdaugh Jr., and Eugene D. Robin

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

Find articles by Cross, C. in: PubMed | Google Scholar

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

Find articles by Packer, B. in: PubMed | Google Scholar

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

Find articles by Altman, M. in: PubMed | Google Scholar

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

Find articles by Gee, J. in: PubMed | Google Scholar

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

Find articles by Murdaugh, H. in: PubMed | Google Scholar

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

Find articles by Robin, E. in: PubMed | Google Scholar

Published October 1, 1968 - More info

Published in Volume 47, Issue 10 on October 1, 1968
J Clin Invest. 1968;47(10):2402–2410. https://doi.org/10.1172/JCI105923.
© 1968 The American Society for Clinical Investigation
Published October 1, 1968 - Version history
View PDF
Abstract

A method is described for the measurement of total body exchangeable oxygen stores (TBO2). It is based on the dilution of the stable oxygen isotope, 18O2, by the body exchangeable oxygen stores under circumstances in which 18O2 steady-state equilibrium was evaluated simultaneously for both arterial and venous blood compartments. After evaluation of several simplifying assumptions, TBO2 values in dog, normal man, and anemic patients were measured. The magnitude of the exchangeable nonlung oxygen stores was 11.0 ± 3.1 ml/kg (SD) in 5 dogs, 11.9 ± 2.1 ml/kg in 10 normal subjects, and 7.0 ± 1.6 ml/kg in 8 patients with severe anemia (hematocrits of 25% or less).

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 2402
page 2402
icon of scanned page 2403
page 2403
icon of scanned page 2404
page 2404
icon of scanned page 2405
page 2405
icon of scanned page 2406
page 2406
icon of scanned page 2407
page 2407
icon of scanned page 2408
page 2408
icon of scanned page 2409
page 2409
icon of scanned page 2410
page 2410
Version history
  • Version 1 (October 1, 1968): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts