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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Akiyoshi Uemura, … , George D. Yancopoulos, Shin-Ichi Nishikawa
Akiyoshi Uemura, … , George D. Yancopoulos, Shin-Ichi Nishikawa
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1619-1628. https://doi.org/10.1172/JCI15621.
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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

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Abstract

Research Article

Authors

Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa

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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis
Christine Fritsch, … , Marc S. Levin, Deborah C. Rubin
Christine Fritsch, … , Marc S. Levin, Deborah C. Rubin
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1629-1641. https://doi.org/10.1172/JCI13588.
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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis

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Abstract

Research Article

Authors

Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin

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Modulation of tumor growth by inhibitory Fcγ receptor expressed by human melanoma cells
Lydie Cassard, … , Wolf H. Fridman, Catherine Sautès-Fridman
Lydie Cassard, … , Wolf H. Fridman, Catherine Sautès-Fridman
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1549-1557. https://doi.org/10.1172/JCI15454.
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Modulation of tumor growth by inhibitory Fcγ receptor expressed by human melanoma cells

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Abstract

Research Article

Authors

Lydie Cassard, Joël F.G. Cohen-Solal, Annie Galinha, Xavier Sastre-Garau, Claire Mathiot, Jérôme Galon, Thierry Dorval, Alain Bernheim, Wolf H. Fridman, Catherine Sautès-Fridman

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Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo
Wolfgang E. Gallwitz, … , Theresa A. Guise, Gregory R. Mundy
Wolfgang E. Gallwitz, … , Theresa A. Guise, Gregory R. Mundy
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1559-1572. https://doi.org/10.1172/JCI11936.
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Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo

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Abstract

Research Article

Authors

Wolfgang E. Gallwitz, Theresa A. Guise, Gregory R. Mundy

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PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
Dipak Panigrahy, … , Judah Folkman, Arja Kaipainen
Dipak Panigrahy, … , Judah Folkman, Arja Kaipainen
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):923-932. https://doi.org/10.1172/JCI15634.
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PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis

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Abstract

Research Article

Authors

Dipak Panigrahy, Samuel Singer, Lucy Q. Shen, Catherine E. Butterfield, Deborah A. Freedman, Emy J. Chen, Marsha A. Moses, Susan Kilroy, Stefan Duensing, Christopher Fletcher, Jonathan A. Fletcher, Lynn Hlatky, Philip Hahnfeldt, Judah Folkman, Arja Kaipainen

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UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells
Sumayah Jamal, Robert J. Schneider
Sumayah Jamal, Robert J. Schneider
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):443-452. https://doi.org/10.1172/JCI13729.
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UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells

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Abstract

Research Article

Authors

Sumayah Jamal, Robert J. Schneider

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Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
Flavio Curnis, … , Angelina Sacchi, Angelo Corti
Flavio Curnis, … , Angelina Sacchi, Angelo Corti
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):475-482. https://doi.org/10.1172/JCI15223.
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Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration

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Abstract

Research Article

Authors

Flavio Curnis, Angelina Sacchi, Angelo Corti

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Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival
Dinesh S. Rao, … , Martin G. Sanda, Theodora S. Ross
Dinesh S. Rao, … , Martin G. Sanda, Theodora S. Ross
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):351-360. https://doi.org/10.1172/JCI15529.
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Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival

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Abstract

Research Article

Authors

Dinesh S. Rao, Teresa S. Hyun, Priti D. Kumar, Ikuko F. Mizukami, Mark A. Rubin, Peter C. Lucas, Martin G. Sanda, Theodora S. Ross

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G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells
April L. Blajeski, … , Timothy J. Kottke, Scott H. Kaufmann
April L. Blajeski, … , Timothy J. Kottke, Scott H. Kaufmann
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):91-99. https://doi.org/10.1172/JCI13275.
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G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells

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Abstract

Research Article

Authors

April L. Blajeski, Vy A. Phan, Timothy J. Kottke, Scott H. Kaufmann

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Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Rebecca S. Muraoka, … , Victor Koteliansky, Carlos L. Arteaga
Rebecca S. Muraoka, … , Victor Koteliansky, Carlos L. Arteaga
Published June 15, 2002
Citation Information: J Clin Invest. 2002;109(12):1551-1559. https://doi.org/10.1172/JCI15234.
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Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

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Abstract

TGF-βs are potent inhibitors of epithelial cell proliferation. However, in established carcinomas, autocrine/paracrine TGF-β interactions can enhance tumor cell viability and progression. Thus, we studied the effect of a soluble Fc:TGF-β type II receptor fusion protein (Fc:TβRII) on transgenic and transplantable models of breast cancer metastases. Systemic administration of Fc:TβRII did not alter primary mammary tumor latency in MMTV-Polyomavirus middle T antigen transgenic mice. However, Fc:TβRII increased apoptosis in primary tumors, while reducing tumor cell motility, intravasation, and lung metastases. These effects correlated with inhibition of Akt activity and FKHRL1 phosphorylation. Fc:TβRII also inhibited metastases from transplanted 4T1 and EMT-6 mammary tumors in syngeneic BALB/c mice. Tumor microvessel density in a mouse dorsal skin window chamber was unaffected by Fc:TβRII. Therefore, blockade of TGF-β signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas.

Authors

Rebecca S. Muraoka, Nancy Dumont, Christoph A. Ritter, Teresa C. Dugger, Dana M. Brantley, Jin Chen, Evangeline Easterly, L. Renee Roebuck, Sarah Ryan, Philip J. Gotwals, Victor Koteliansky, Carlos L. Arteaga

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