Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

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Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa

Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis

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Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin

Modulation of tumor growth by inhibitory Fcγ receptor expressed by human melanoma cells

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Lydie Cassard, Joël F.G. Cohen-Solal, Annie Galinha, Xavier Sastre-Garau, Claire Mathiot, Jérôme Galon, Thierry Dorval, Alain Bernheim, Wolf H. Fridman, Catherine Sautès-Fridman

Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo

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Wolfgang E. Gallwitz, Theresa A. Guise, Gregory R. Mundy

PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis

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Dipak Panigrahy, Samuel Singer, Lucy Q. Shen, Catherine E. Butterfield, Deborah A. Freedman, Emy J. Chen, Marsha A. Moses, Susan Kilroy, Stefan Duensing, Christopher Fletcher, Jonathan A. Fletcher, Lynn Hlatky, Philip Hahnfeldt, Judah Folkman, Arja Kaipainen

UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells

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Sumayah Jamal, Robert J. Schneider

Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration

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Flavio Curnis, Angelina Sacchi, Angelo Corti

Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival

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Dinesh S. Rao, Teresa S. Hyun, Priti D. Kumar, Ikuko F. Mizukami, Mark A. Rubin, Peter C. Lucas, Martin G. Sanda, Theodora S. Ross

G₁ and G₂ cell-cycle arrest following microtubule depolymerization in human breast cancer cells

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April L. Blajeski, Vy A. Phan, Timothy J. Kottke, Scott H. Kaufmann

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

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TGF-βs are potent inhibitors of epithelial cell proliferation. However, in established carcinomas, autocrine/paracrine TGF-β interactions can enhance tumor cell viability and progression. Thus, we studied the effect of a soluble Fc:TGF-β type II receptor fusion protein (Fc:TβRII) on transgenic and transplantable models of breast cancer metastases. Systemic administration of Fc:TβRII did not alter primary mammary tumor latency in MMTV-Polyomavirus middle T antigen transgenic mice. However, Fc:TβRII increased apoptosis in primary tumors, while reducing tumor cell motility, intravasation, and lung metastases. These effects correlated with inhibition of Akt activity and FKHRL1 phosphorylation. Fc:TβRII also inhibited metastases from transplanted 4T1 and EMT-6 mammary tumors in syngeneic BALB/c mice. Tumor microvessel density in a mouse dorsal skin window chamber was unaffected by Fc:TβRII. Therefore, blockade of TGF-β signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas.

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Rebecca S. Muraoka, Nancy Dumont, Christoph A. Ritter, Teresa C. Dugger, Dana M. Brantley, Jin Chen, Evangeline Easterly, L. Renee Roebuck, Sarah Ryan, Philip J. Gotwals, Victor Koteliansky, Carlos L. Arteaga