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Viewpoint

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Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum
Jill E. Weatherhead, … , Robert L. Atmar, Prathit A. Kulkarni
Jill E. Weatherhead, … , Robert L. Atmar, Prathit A. Kulkarni
Published October 27, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI145301.
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Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum

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Abstract

Available evidence suggests significant heterogeneity in the human immune response to SARS-CoV-2. In this Viewpoint, we examine the spectrum of SARS-CoV-2-associated clinical inflammatory syndromes identified in adult and pediatric populations to date. A better understanding of the immunopathologies and related clinical manifestations of these syndromes is necessary to improve their diagnosis and management.

Authors

Jill E. Weatherhead, Eva H. Clark, Tiphanie P. Vogel, Robert L. Atmar, Prathit A. Kulkarni

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Promoting the success of women and minority physician-scientists in academic medicine: a dean’s perspective
Nancy J. Brown
Nancy J. Brown
Published October 6, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI144526.
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Promoting the success of women and minority physician-scientists in academic medicine: a dean’s perspective

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Abstract

Dr. Nancy Brown, Dean of the Yale School of Medicine, shares her perspective on the challenges facing women and minority faculty members and trainees in academic medicine and provides a reflection on how leaders in academic medicine can promote diversity, equity, and inclusion to enhance their success.

Authors

Nancy J. Brown

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Towards realizing diversity in academic medicine
John M. Carethers
John M. Carethers
Published September 29, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI144527.
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Towards realizing diversity in academic medicine

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Abstract

Dr. John Carethers discusses challenges to the advancement of underrepresented minorities in medicine and effective strategies for institutions to promote diversity. He proposes that diversity should be a fourth pillar in the mission of academic medicine, alongside research, education, and clinical care.

Authors

John M. Carethers

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Reflections of a Black woman physician-scientist
Rotonya M. Carr
Rotonya M. Carr
Published September 24, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI144525.
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Reflections of a Black woman physician-scientist

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Abstract

Dr. Rotonya Carr provides her thoughts on being one of the only Black women in her field, the persistent race-gender gap among academic medical center faculty, and possible solutions to retaining and promoting Black women in academia.

Authors

Rotonya M. Carr

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Drugs of unproven benefit for COVID-19: a pharma perspective on ethical allocation of available therapies
Arthur L. Caplan, … , Karla Childers, Aran Maree
Arthur L. Caplan, … , Karla Childers, Aran Maree
Published September 15, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI144186.
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Drugs of unproven benefit for COVID-19: a pharma perspective on ethical allocation of available therapies

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Abstract

In the quest to provide treatment for COVID-19 patients, available therapies that have been approved for other indications but have insufficient evidence of safety and efficacy for use against COVID-19 have been considered. One of the unintended consequences of this approach is the potential creation of shortages, depriving existing patients who are benefiting from products based on their proven indications. Here, a pharmaceutical company outlines their ethical decision-making framework to guide decision-making and ensure equity of access to products.

Authors

Arthur L. Caplan, Joanne Waldstreicher, Karla Childers, Aran Maree

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Immune pathogenesis of COVID-19-related Multisystem Inflammatory Syndrome in Children (MIS-C)
Anne H. Rowley, … , Stanford T. Shulman, Moshe Arditi
Anne H. Rowley, … , Stanford T. Shulman, Moshe Arditi
Published September 1, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI143840.
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Immune pathogenesis of COVID-19-related Multisystem Inflammatory Syndrome in Children (MIS-C)

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Abstract

Several important features of Multisystem Inflammatory Syndrome in Children (MIS-C) differentiate it from Kawasaki disease. Rowley et al. discuss what is known about MIS-C and the need to elucidate the specific immune mechanisms underlying hyperinflammatory syndromes caused by SARS-CoV-2 to advance potential targeted treatments and prevention efforts.

Authors

Anne H. Rowley, Stanford T. Shulman, Moshe Arditi

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A deliberate path toward diversity, equity, and inclusion within the ASCI
Lorraine B. Ware, … , John B. Hawley, Rexford S. Ahima
Lorraine B. Ware, … , John B. Hawley, Rexford S. Ahima
Published August 24, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI142423.
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A deliberate path toward diversity, equity, and inclusion within the ASCI

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Abstract

Authors

Lorraine B. Ware, Kathleen L. Collins, John B. Hawley, Rexford S. Ahima

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COVID-19, racism, and the pursuit of health care and research worthy of trust
Lisa A. Cooper, Deidra C. Crews
Lisa A. Cooper, Deidra C. Crews
Published July 30, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI141562.
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COVID-19, racism, and the pursuit of health care and research worthy of trust

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Abstract

This Viewpoint describes how physicians and researchers can utilize approaches based on relationship-centered care and structural competence to reduce racism and enhance trustworthiness in health care and biomedical research.

Authors

Lisa A. Cooper, Deidra C. Crews

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The unsettled science of nonrenal calcitriol production and its clinical relevance
J. Wesley Pike, Mark B. Meyer
J. Wesley Pike, Mark B. Meyer
Published July 27, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI141334.
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The unsettled science of nonrenal calcitriol production and its clinical relevance

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Abstract

Authors

J. Wesley Pike, Mark B. Meyer

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Toward an equitable society: building a culture of antiracism in health care
Eugenia C. South, … , Paris D. Butler, Raina M. Merchant
Eugenia C. South, … , Paris D. Butler, Raina M. Merchant
Published July 21, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI141675.
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Toward an equitable society: building a culture of antiracism in health care

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Abstract

Addressing racism from within health care is critically important to creating an equitable society. Here, we provide an actionable framework that can be implemented to build a culture of antiracism in health care systems.

Authors

Eugenia C. South, Paris D. Butler, Raina M. Merchant

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