The COVID-19 pandemic has been exacerbated in the US by misinformation and disregard for public health recommendations. In this Viewpoint, Peter Hotez explores the anti-science movement in America, emphasizing our unique historical connections to health and medical freedom.
Peter J. Hotez
In recent months genomic characterization of pandemic SARS-CoV-2 isolates identified viral variants that are less susceptible to neutralization by convalescent plasma (CP), vaccine-elicited plasma/sera, or SARS-CoV-2 monoclonal antibodies than earlier SARS-CoV-2 strains. In this Viewpoint, Casadevall et al. argue against the causal association made in some press articles between the emergence of SARS-CoV-2 variants and convalescent plasma use.
Arturo Casadevall, Jeffrey Henderson, Michael Joyner, Liise-anne Pirofski
Seth Blackshaw, Joshua R. Sanes
Jeffrey C. Rathmell, W. Kimryn Rathmell
Louis J. Ptáček, Ying-Hui Fu
E. Dale Abel
Robert V. Farese Jr., Tobias C. Walther
Limited evidence exists regarding the use of the currently approved COVID-19 mRNA vaccines (Pfizer-BioNtech BNT162b2 and Moderna mRNA-1273) during pregnancy. In this Viewpoint, Klein et al. discuss gaps in knowledge and make recommendations to incorporate age, sex, and pregnancy in the preclinical and clincal vaccine development pipeline.
Sabra L. Klein, Patrick S. Creisher, Irina Burd
In this viewpoint, Robert Califf, former commissioner of the U.S. Food and Drug Administration, and colleagues reflect on how to approach questions about which patient treatments and strategies work, particularly in light of the tremendous pressure on the government and biomedical research enterprise to quickly develop safe, effective therapies during the SARS-CoV-2 pandemic.
Robert M. Califf, Lesley H. Curtis, Robert A. Harrington, Adrian F. Hernandez, Eric D. Peterson
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