Aging

Series edited by Christopher Newgard and Norman Sharpless

Aging is an inevitable facet of life. However, research into the molecular mechanisms of aging suggests potential targets that could be therapeutically modified to slow the aging process and increase the span of healthy living. The articles in this series explore selected cellular mechanisms of aging and their link to age-related clinical conditions. These mechanisms include short telomeres, the induction of the senescence-associated secretory phenotype (SASP) in systemic aging, sirtuin regulation of metabolism and aging-associated diseases, mitochondrial metabolism in aging, the mTOR signaling pathway and longevity, aging and immune system function, and aging-associated changes in pancreatic β-cells.

Published March 2013

Cardiology

Series edited by Eugene Braunwald

Despite incredible progress in cardiology research, cardiovascular disease remains the leading cause of death in industrialized nations. The reviews in this series explore selected areas of cardiovascular research that show promising translational potential. Areas of interest include therapeutic antagomirs targeting cardiac microRNAs, the genetic basis of cardiomyopathies and cardiac arrhythmias, the role of chronic inflammation in atherosclerosis, S-nitrosylation in vasodilatation, as well as emerging approaches to treat heart failure, such as gene therapy, stem cell regeneration, therapeutics that restore normal calcium cycling, and interventions to reduce reperfusion injury following myocardial infarction. Advances stemming from these ongoing research efforts may soon be poised to make an impact on the clinical management of cardiovascular disease. Image credit: BSIP / Science Source.

Published January 2013

Lymphoid malignancy

Series edited by Riccardo Dalla-Favera

Cancers derived from lymphoid cells, including B cell and T cell lineages, often exhibit aberrant processes of lymphoid differentiation or activation, resulting in a broad spectrum of diverse and complex lymphomas and leukemias. The reviews in this series focus on recent progress in selected lymphoid malignancies, with an emphasis on the molecular mechanisms and genetic alterations that drive oncogenesis, including new mutations identified by genome-wide analyses. These newly identified genes are improving our mechanistic understanding of how these cancers develop and progress, and provide new opportunities for therapeutic intervention. Cover image credit: Aaron Polliack / Photo Researchers, Inc.

Published October 2012

Pulmonology

Series edited by Paul W. Noble

In addition to the critical function of gas exchange, our lungs also serve as an important barrier between our bodies and the environment. The reviews in this series explore all aspects of the lung, from the developmental processes that generate the barrier, to the immune reactions that drive conditions like asthma, to the cell biology that underlies acute respiratory distress and pulmonary fibrosis. In a turn toward clinical medicine, this series also addresses how basic research has contributed to the development of new therapeutic strategies for pulmonary disease. Cover image credit: Shutterstock, Inc. Copyright: Sebastian Kaulitzki

Published August 2012

Neuroimmunology

Series edited by Lawrence Steinman

Hidden behind the blood brain and blood CSF barriers, the nervous system is often considered an area of immune privilege, lacking the surveillance system that guards the rest of our bodies against infection. However, the reviews in this series reveal that the immune and nervous systems are actually inextricably linked. In addition to physical connections, the two systems share common signaling molecules and pathways, and the mechanics of cell-cell interactions in both systems are remarkably similar. Disturbance of the immune system of the brain is linked to important human conditions like multiple sclerosis, Alzheimer’s Disease, and other neurodegenerative diseases. Cover image credit: Photo Researchers

Published April 2012

Dermatology

Series edited by John R. Stanley

Though it's the first thing we see when we look at each other, the skin may be occasionally forgotten as a site of clinically important disease. The reviews in this series highlight our current understanding of several common dermatological conditions, and describe how research in the field has played a major role in expanding our understanding of the basic biology of stem cells and cancer. Correspondingly, basic research findings have led to new insights into dermatological disease, often with impact on therapeutic strategies. Cover image credit: John Seykora

Published February 2012

Sexually transmitted infections

Series edited by Anne Rompalo

Sexually transmitted infections (STIs) are major health problems worldwide, and despite identification of the causative agents and understanding of the mechanism of transmission, many have continued to grow in prevalence. Untreated, STIs may complicate pregnancy and fertility, lead to stillbirth, or result in chronic disease or death. Decades of research have offered glimpses into the pathophysiology of many of these diseases, but as the reviews in this series make clear, a deeper understanding of the natural history of infection, the molecular biology of the agents, and the environment of the hosts they invade will be necessary to achieve their control and eradication. Cover image credit: Thomas Quinn

Published December 2011

Breast Cancer Heterogeneity

Series edited by Kornelia Polyak

Breast cancer is one of the leading causes of death among women in the United States. However, as the Reviews in this series make clear, breast cancer is a group of heterogeneous diseases, with vastly different courses, prognoses, and outcomes. As technologies advance, we are rapidly approaching an integrated understanding of this family of cancers, from the tumor cell of origin and genetic alterations that license uncontrolled cell division, to the unique contributions of the surrounding non-cancerous tissue that can support or suppress growth. This research may improve the outlook for millions of patients by making more targeted therapies a reality.
Image credit: Vanessa Almendro.

Published October 2011

Obesity

Series edited by Rexford Ahima

The World Health Organization estimates that 1 in 10 adults are obese, and as this epidemic expands world wide, the associated morbidities, including diabetes and heart disease, increase in prevalence as well. The reviews in this series make clear that obesity is a multi-organ, multi-system disease, with both genetic and environmental components. In addition, they highlight how recent breakthroughs in a variety of scientific fields – from an improved understanding the neural circuits that drive eating behavior to the identification of proteins that regulate fat storage- might lead to novel therapeutic strategies.

Published June 2011

Huntington Disease

Series edited by

Huntington disease (HD) is a progressive neurodegenerative disorder for which there is currently no effective therapy, despite the causative genetic defect that underlies the disease - a mutation in the huntingtin gene - being discovered almost two decades ago. The articles in this Review Series describe some of the recent advances in understanding HD at the molecular level and highlight some of the innovative therapeutic approaches that are moving towards the clinic, offering hope for families with this devastating disease.

Published February 2011