Targets for cancer therapy

Series edited by William G. Kaelin, Jr.

The series reviews a number of cellular processes that provide cancer drug targets, including angiogenesis, cell cycle and checkpoint control, growth factor signaling, and apoptosis. It also discusses target selection based on genomics and the specific case of the Abl inhibitor Gleevec.

Published December 1999

Alzheimer's disease

Series edited by Sangram Sisodia

Articles in the series highlight recent advances pertaining to the accuracy of clinico-pathological diagnoses, genetic risk factors, mechanisms of disease, and therapeutic strategies, and point to areas for future investigations.

Published November 1999

Asthma

Series edited by Jack A. Elias

The series summarizes recent advances in elucidating the molecular and cellular etiology of asthma. Specific topics covered include the roles of IgE, chemokines, and Th2 cells, as well as early life origins of the disease and airway remodeling seen in patients.

Published October 1999

Angiogenesis

Series edited by David Cheresh

Therapeutic manipulation of angiogenesis would be desirable for the treatment of a variety of diseases, including cancer and heart disease. This short series focuses this therapeutic potential and specifically on integrins and matrix metalloproteinases as potential targets.

Published May 1999

Protein-protein interaction domains in signal transduction

Series edited by Alan R. Saltiel and Benjamin L. Margolis

Signal transduction depends on a series of direct interaction between molecules, both on the cell surface and intracellularly. The series discusses the molecular basis for the formation of transient protein complexes.

Published March 1999

Cystic fibrosis

Series edited by James M. Wilson

This series summarizes the current knowledge of the molecular basis for cystic fibrosis and reviews the state of gene therapeutic and pharmacological strategies for therapeutic intervention.

Published February 1999