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Review Series

Cellular responses to aggregated proteins associated with human disease

Series edited by David H. Perlmutter

This series discusses our current understanding of protein folding and the mechanisms by which disease-associated proteins aggregate, injure cells, and trigger responses designed to protect cells from such injury.

Articles in series

Series Introduction: The cellular response to aggregated proteins associated with human disease
David H. Perlmutter
David H. Perlmutter
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1219-1220. https://doi.org/10.1172/JCI16780.
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Series Introduction: The cellular response to aggregated proteins associated with human disease

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Abstract

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Authors

David H. Perlmutter

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Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions
Arthur Horwich
Arthur Horwich
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1221-1232. https://doi.org/10.1172/JCI16781.
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Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions

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Authors

Arthur Horwich

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Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease
Dennis J. Selkoe
Dennis J. Selkoe
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1375-1381. https://doi.org/10.1172/JCI16783.
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Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease

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Authors

Dennis J. Selkoe

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Translational control in the endoplasmic reticulum stress response
David Ron
David Ron
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1383-1388. https://doi.org/10.1172/JCI16784.
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Translational control in the endoplasmic reticulum stress response

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Authors

David Ron

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Orchestrating the unfolded protein response in health and disease
Randal J. Kaufman
Randal J. Kaufman
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1389-1398. https://doi.org/10.1172/JCI16886.
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Orchestrating the unfolded protein response in health and disease

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Authors

Randal J. Kaufman

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Liver injury in α1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury
David H. Perlmutter
David H. Perlmutter
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1579-1583. https://doi.org/10.1172/JCI16787.
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Liver injury in α1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

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Authors

David H. Perlmutter

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α1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy
David A. Lomas, Ravi Mahadeva
David A. Lomas, Ravi Mahadeva
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1585-1590. https://doi.org/10.1172/JCI16782.
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α1-Antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

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David A. Lomas, Ravi Mahadeva

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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis
Marina S. Gelman, Ron R. Kopito
Marina S. Gelman, Ron R. Kopito
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1591-1597. https://doi.org/10.1172/JCI16786.
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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis

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Authors

Marina S. Gelman, Ron R. Kopito

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