Ischemia arises when demands for energy substrates (primarily oxygen and glucose) are not matched by supply. The consequences differ depending on the affected tissue, and the series covers the effects of ischemia in a number of different tissues and organs.
Published January 2000
The series reviews a number of cellular processes that provide cancer drug targets, including angiogenesis, cell cycle and checkpoint control, growth factor signaling, and apoptosis. It also discusses target selection based on genomics and the specific case of the Abl inhibitor Gleevec.
Published December 1999
Articles in the series highlight recent advances pertaining to the accuracy of clinico-pathological diagnoses, genetic risk factors, mechanisms of disease, and therapeutic strategies, and point to areas for future investigations.
Published November 1999
The series summarizes recent advances in elucidating the molecular and cellular etiology of asthma. Specific topics covered include the roles of IgE, chemokines, and Th2 cells, as well as early life origins of the disease and airway remodeling seen in patients.
Published October 1999
Therapeutic manipulation of angiogenesis would be desirable for the treatment of a variety of diseases, including cancer and heart disease. This short series focuses this therapeutic potential and specifically on integrins and matrix metalloproteinases as potential targets.
Published May 1999
Signal transduction depends on a series of direct interaction between molecules, both on the cell surface and intracellularly. The series discusses the molecular basis for the formation of transient protein complexes.
Published March 1999
This series summarizes the current knowledge of the molecular basis for cystic fibrosis and reviews the state of gene therapeutic and pharmacological strategies for therapeutic intervention.
Published February 1999